Dehydroevodiamine

Dehydroevodiamine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.

• Verwenden

  Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.

• Biologische Aktivität

  Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.

• Physiological effects

  Dehydroevodiamine has an antihypertensive and antitumor effects.

• in vitro

  Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.

  Western Blot Analysis

  Cell Line: td>	RAW 264.7 macrophage cells
  Concentration:	10 μM, 30 μM, 50 μM
  Incubation Time:	pretreated 2 hours
  Result:	Reduced iNOS and COX-2 expression and increased IκB-α expression.

  RT-PCR

  < td class="col1"> Cell Line: td>

  RAW 264.7 macrophage cells
  Concentration:	10 μM, 30 μM, 50 μM
  Incubation Time:	pretreated 2 hours
  Result:	Reduced iNOS and COX-2 mRNA expression.

• target

  Target	Value
  NF-κB ()
  COX-2 ()
  iNOS ()
  PGE2 ()

Dehydroevodiamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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