Harminhydrochlorid

Bezeichnung:Harminhydrochlorid

CAS-Nr343-27-1

Englisch Name:HARMINE HYDROCHLORIDE

CBNumberCB4780696

SummenformelC13H13ClN2O

Molgewicht248.71

MOL-Datei343-27-1.mol

Synonyma

Harminhydrochlorid

Harminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	265-270°C
storage temp.	2-8°C
Löslichkeit	Soluble in Water (up to 25 mg/ml).
Aggregatzustand	powder
Farbe	off-white to pale green
Merck	14,4616
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
LogP	3.173 (est)
CAS Datenbank	343-27-1(CAS DataBase Reference)
EPA chemische Informationen	Harmine hydrochloride (343-27-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-40
S-Sätze:	22-36
RIDADR	1544
WGK Germany	3
RTECS-Nr.	MG9450000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29339900

Gefahreninformationscode (GHS)

HARMINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50?= 8 μM).1?Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50‘s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3?Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC’s) possibly via inhibition of Akt phosphorylation.4?Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5?Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6
Chemische Eigenschaften
yellow to slightly green crystalline powder
Verwenden
Harmine Monohydrochloride is an anti-viral agents for the treatment of EV71 infection. It inhibits enterovirus 71 replication by targeting NF-κB pathway.
läuterung methode
The hydrate crystallises as fluorescent crystals from water. The anhydrous salt has m 319o. [Beilstein 23/12 V 237.]
Einzelnachweise
1) Wouters (1998)?Structural Aspects of Monoamine Oxidase and its Reversible Inhibition?Current Medicinal Chemistry,?5?137 2) Seifert?et al. (2008)?DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine; FEBS J.,?275?6268 3) Gockler?et al. (2009)?Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite outgrowth; FEBS J.,?276?6324 4) Liu?et al. (2013)?Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma; J .Neurooncol.,?112?39 5) Patel?et al. (2012)?A review on medical importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid ‘Harmine’; Asian Pac. J. Trop. Biomed.,?2?660 6) Yoneazwa?et al. (2011)?Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo; Eur. J. Pharmacol.,?650?511

Harminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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