4-HYDROXY PROPRANOLOL HCL

Bezeichnung:4-HYDROXY PROPRANOLOL HCL

CAS-Nr14133-90-5

Englisch Name:4-HYDROXY PROPRANOLOL HCL

CBNumberCB4752444

SummenformelC16H21NO3.ClH

Molgewicht311.8

MOL-Datei14133-90-5.mol

4-HYDROXY PROPRANOLOL HCL physikalisch-chemischer Eigenschaften

Schmelzpunkt	156-158°C
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Pale Red to Black
Stabilität	Hygroscopic

4-HYDROXY PROPRANOLOL HCL Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Solid
Verwenden
A metabolite of Propranolol.
Verwenden
The main metabolite of (S)-Propranolol
Verwenden
The main metabolite of (R)-Propranolol
Biologische Aktivität
(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.
in vitro
compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].
in vivo
rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].
IC 50
1.1 μm: inhibits lipid peroxidation in endothelial cells.
Einzelnachweise
[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.

4-HYDROXY PROPRANOLOL HCL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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