Amcinonid

Bezeichnung:Amcinonid

CAS-Nr51022-69-6

Englisch Name:AMCINONIDE

CBNumberCB4419202

SummenformelC28H35FO7

Molgewicht502.57

MOL-Datei51022-69-6.mol

Synonyma

Amcinonid

Amcinonid physikalisch-chemischer Eigenschaften

Schmelzpunkt	>216°C (dec.)
Siedepunkt	635.9°C (rough estimate)
Dichte	1.33±0.1 g/cm3 (20 ºC 760 Torr)
Brechungsindex	1.5860 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	Acetonitrile (Slightly), Dichlomethane (Slightly), Dioxane (Slightly), Methanol
pka	13.09±0.70(Predicted)
Farbe	White to Off-White

Sicherheit

WGK Germany	2
RTECS-Nr.	TU3682500
HS Code	2937220000

Gefahreninformationscode (GHS)

AMCINONIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Cyclocort,Lederle,US,1979
Verwenden
antiinflammatory
Verwenden
Glucocorticoid.
Definition
ChEBI: Amcinonide is a corticosteroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 20-oxo steroid, an acetate ester, a spiroketal and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug. It derives from a hydride of a pregnane.
Manufacturing Process
An 11.1 g (24.1 mmol) portion of the compound 16α,17α- cyclopentylidenedioxy-9α-fluoro-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione is placed in a 250 ml round-bottom flask. A 100 ml portion of pyridine is added and the mixture is stirred to a complete solution. A 5.5 ml (54.6 mmol) portion of acetic anhydride is added dropwise and the mixture is stirred for 2% hours. An 11 ml portion of methanol is added and the mixture is stirred an additional hour. This mixture is concentrated under reduced pressure to about 10 to 15 ml and then poured slowly into a mixture of ice, water and dilute hydrochloric acid. This mixture is stirred and the solid which forms is collected by filtration, washed with water to a neutral pH and air dried yielding 11.5 g. This solid is taken up in hot acetone, treated with activated charcoal and filtered while hot through diatomaceous earth. The filtrate is concentrated on a steam bath while adding n-hexane to the point of incipient crystallization. This mixture is allowed to cool to room temperature. The solid which forms is collected by filtration, washed with acetone-n-hexane (1:14) and air dried yielding 7.0 g of the desired product.
Trademarks
Cyclocort (Astellas.
Therapeutic Function
Topical corticosteroid, Antiinflammatory
Allgemeine Beschreibung
Amcinonide, 21-(acetyloxy)-16α,17-[cyclopentylidenebis(oxy)]-9-fluoro-11β-hydroxypregna-1,4-diene-3,20-dione (Cyclocort).

AMCINONIDE Upstream-Materialien And Downstream Produkte

Amcinonid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

51022-69-6, AMCINONIDE Verwandte Suche:

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