Bakuchiol

Bezeichnung:Bakuchiol

CAS-Nr10309-37-2

Englisch Name:Bakuchiol

CBNumberCB4365255

SummenformelC18H24O

Molgewicht256.38

MOL-Datei10309-37-2.mol

Bakuchiol physikalisch-chemischer Eigenschaften

Siedepunkt	391℃
Dichte	0.963
Dampfdruck	0Pa at 25℃
Brechungsindex	1.4500 (estimate)
Flammpunkt	177℃
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
pka	10.10±0.26(Predicted)
Farbe	Oil
Optische Aktivität	[α]/D +24.0 to +30.0°, c = 0.1 in chloroform
BRN	3611720
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey	LFYJSSARVMHQJB-WYMLVPIESA-N
LogP	5.09 at 20℃ and pH6.31
Oberflächenspannung	43.92mN/m at 1g/L and 20℃

Sicherheit

WGK Germany	3
RTECS-Nr.	SL3785000
Toxizität	LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80

Gefahreninformationscode (GHS)

Bakuchiol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects.
Verwenden
(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.
Sicherheitsprofil
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes.
Mode of action
The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6].
Einzelnachweise
1) Adhikari et al. (2007), Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants; J. Clin. Biochem. Nutr., 40 174
2) Kim et al. (2013), Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage; Toxicol. Appl. Pharmacol., 269 109
3) Zhang et al. (2017), Bakuchiol protects against acute lung injury in septic mice; Inflammation, 40 351
4) Kim et al. (2016), Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia; Molecules, 21 E1076
[5] Zhenlong Xin . “Bakuchiol: A newly discovered warrior against organ damage.” Pharmacological research 141 (2019): Pages 208-213.
[6] Jianyu Feng. “Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1.” Apoptosis 71 1 (2016): 532–545.

Bakuchiol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

10309-37-2, Bakuchiol Verwandte Suche:

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