FILIPIN COMPLEX Struktur

FILIPIN COMPLEX

Bezeichnung:FILIPIN COMPLEX

CAS-Nr11078-21-0

Englisch Name:FILIPIN COMPLEX

CBNumberCB4291136

SummenformelC35H58O11

Molgewicht654.82842

MOL-Datei11078-21-0.mol

FILIPIN COMPLEX physikalisch-chemischer Eigenschaften

Schmelzpunkt	195-205°
alpha	D22 -148.3° (c = 0.89 in methanol)
storage temp.	−20°C
Löslichkeit	methanol: 10 mg/mL, clear, very dark yellow
Aggregatzustand	powder
Farbe	yellow
Merck	13,4111

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	LK4400000
F	10
HS Code	2941900000

Gefahreninformationscode (GHS)

FILIPIN COMPLEX Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.
Verwenden
Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.
Definition
ChEBI: Filipin III is a macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis. It has a role as a bacterial metabolite and a fluorescent probe. It is a macrolide, a polyol and an olefinic compound.
Allgemeine Beschreibung
Chemical structure: macrolide
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

FILIPIN COMPLEX Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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