SR 202 Struktur

SR 202

Bezeichnung:SR 202

CAS-Nr76541-72-5

Englisch Name:SR 202

CBNumberCB4285085

SummenformelC11H17ClO7P2

Molgewicht358.65

MOL-Datei76541-72-5.mol

SR 202 physikalisch-chemischer Eigenschaften

Siedepunkt	436.6±45.0 °C(Predicted)
Dichte	1.355±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO: 5 mg/mL
Aggregatzustand	crystalline
Farbe	white
Wasserlöslichkeit	Soluble to 100 mM in water

Sicherheit

S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	TB8817000

Gefahreninformationscode (GHS)

SR 202 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
SR 202 is a noniodinated, potential lipid-altering agent and an inhibitor of the peripheral conversion of T4 to T3 associated with thyroid hormone metabolism.
Verwenden
Anti-atherosclerotic.
Definition
ChEBI: Phosphoric acid [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl ester is a trialkyl phosphate.
Trademarks
Clenicor (Symphar S.A.,Switzerland).
Biologische Aktivität
Selective PPAR γ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPAR γ transcriptional activity (IC 50 = 140 μ M) without affecting ligand-stimulated PPAR α , PPAR β or FXR transcriptional activity. Inhibits PPAR γ -dependent adipocyte differentiation and growth in vitro and in vivo . Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo .
in vitro
sr-202 is a specific antagonist of ppar, which shows selectivity both among the ppar family members and other nuclear receptors. sr-202 also inhibits ppar-dependent differentiation of adipocytes. in cell culture, sr-202 efficiently antagonizes hormone- and tzd induced adipocyte differentiation [1].
in vivo
. decreasing ppar activity by treatment with sr-202 leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance. treatment with sr-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice [1]. when wild-type mice are fed a high-fat diet, the plasma levels of tnf-α are raised, and sr-202 treatment protects against this rise [2]..
IC 50
140 μm for attenuation of troglitazone-induced peroxisome proliferator-activated receptor gamma (ppar) transcriptional activity [1]
Lager
Desiccate at RT
Einzelnachweise
[1] rieusset j, touri f, michalik l, escher p, desvergne b, niesor e, wahli w. a new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. mol endocrinol. 2002 nov;16(11):2628-44.
[2] doggrell s. do peroxisome proliferation receptor-gamma antagonists have clinical potential as combined antiobesity and antidiabetic drugs expert opin investig drugs. 2003 apr;12(4):713-6.

SR 202 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

76541-72-5, SR 202 Verwandte Suche:

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