DANSYLCADAVERINE Struktur

N-(5-Aminopentyl)-5-(dimethylamino)naphthalin-1-sulfonamid

Bezeichnung:N-(5-Aminopentyl)-5-(dimethylamino)naphthalin-1-sulfonamid

CAS-Nr10121-91-2

Englisch Name:DANSYLCADAVERINE

CBNumberCB4266400

SummenformelC17H25N3O2S

Molgewicht335.46

MOL-Datei10121-91-2.mol

Synonyma

N-(5-Aminopentyl)-5-(dimethylamino)naphthalin-1-sulfonamid

N-(5-Aminopentyl)-5-(dimethylamino)naphthalin-1-sulfonamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	137-140 °C
Siedepunkt	505.5±60.0 °C(Predicted)
Dichte	1.190±0.06 g/cm3(Predicted)
storage temp.	−20°C
pka	11.96±0.50(Predicted)
Aggregatzustand	powder
Farbe	Yellow to yellowish green
maximale Wellenlänge (λmax)	335 nm
BRN	2951070
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Biologische Anwendungen	Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
F	10-23

Gefahreninformationscode (GHS)

DANSYLCADAVERINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.
Verwenden
Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.
Verwenden
Lysosomotropic fluorescent Probe
Verwenden
Fluorescent substrate for the assay of transamidating enzymes.
Definition
ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine.
Einzelnachweise
1) Munafo and Colombo (2001),?A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci.,?114?3619 2) Jiang?et al. (2012),?Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol.,?188?1361 3) Haigler?et al.?(1980),?Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239 4) Murthy?et al. (1994),?Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem.,?269?22907

N-(5-Aminopentyl)-5-(dimethylamino)naphthalin-1-sulfonamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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