Cryptotanshinone

Bezeichnung:Cryptotanshinone

CAS-Nr35825-57-1

Englisch Name:Cryptotanshinone

CBNumberCB4222031

SummenformelC19H20O3

Molgewicht296.36

MOL-Datei35825-57-1.mol

Cryptotanshinone physikalisch-chemischer Eigenschaften

Schmelzpunkt	192°C(lit.)
Siedepunkt	459.0±45.0 °C(Predicted)
Dichte	1.23±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ≥5mg/mL
Aggregatzustand	powder
Farbe	orange-brown
Optische Aktivität	[α]/D -85.0±3.0°, c = 0.1 in chloroform
maximale Wellenlänge (λmax)	263nm(lit.)
BRN	5445400
InChIKey	IJSBKZLSTIFYIE-FPKDZHNTSA-N
LogP	4.130 (est)
CAS Datenbank	35825-57-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	25-50/53
S-Sätze:	45-60-61
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany	3
RTECS-Nr.	SF8282645
HazardClass	6.1
PackingGroup	III
HS Code	29321900

Gefahreninformationscode (GHS)

Cryptotanshinone Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Orange powder
Verwenden
Cryptotanshinone (CPT), a lipophilic diterpene derived from the roots of Salvia miltiorrhiza Bge and Salvia przewalskii Maxim, may be used to study its multiple bioactivities as an antibacterial, antidermatophytic, antioxidant, anti-inflammatory and anticancer agent. Cryptotanshinone may also be studied as a differentiation factor.
Verwenden
inhibits angiogenesis
Definition
ChEBI: Cryptotanshinone is an abietane diterpenoid. It has a role as an anticoronaviral agent.
Allgemeine Beschreibung
Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr⁷⁰⁵ phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
Biologische Aktivität
Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.
Biochem/physiol Actions
Cryptotanshinone is an antibacterial and anti-inflammatory compound originally extracted from the roots of Salvia miltiorrhiaz (danshen). Cryptotanshinone has been found to inhibit HIF activation and to inhibit macrophage migration negatively regulate the PI3K pathway. It has demonstrated activity against several strains of Staphylococcus aureus.
Cytotoxicity
IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)
Lager
Room temperature

Cryptotanshinone Upstream-Materialien And Downstream Produkte

Cryptotanshinone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

35825-57-1, Cryptotanshinone Verwandte Suche:

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