Dihydroergotaminmesilat

Bezeichnung:Dihydroergotaminmesilat

CAS-Nr6190-39-2

Englisch Name:DIHYDROERGOTAMINE MESYLATE

CBNumberCB4221630

SummenformelC33H37N5O5.CH4O3S

Molgewicht679.79

MOL-Datei6190-39-2.mol

Synonyma

Dihydroergotaminmesilat

Dihydroergotaminmesilat physikalisch-chemischer Eigenschaften

Schmelzpunkt	232°C
Brechungsindex	-20 ° (C=0.25, JP Method)
storage temp.	Store at RT
Löslichkeit	methanol: 21 mg/mL
Aggregatzustand	powder
Farbe	white
Merck	14,3174
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS Datenbank	6190-39-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
RIDADR	1544
WGK Germany	3
RTECS-Nr.	KE7920000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2939690000

Gefahreninformationscode (GHS)

DIHYDROERGOTAMINE MESYLATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4
Chemische Eigenschaften
White to Off-White Solid
Verwenden
α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.
Verwenden
Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors
Verwenden
vasoconstrictor, antimigraine
Definition
ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens on.
Trademarks
D.H.E. 45 (Valeant); Migranal (Valeant) .
Biologische Aktivität
Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
Lager
Room temperature
Einzelnachweise
Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655 Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15 Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144 Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33

DIHYDROERGOTAMINE MESYLATE Upstream-Materialien And Downstream Produkte

Dihydroergotaminmesilat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6190-39-2, DIHYDROERGOTAMINE MESYLATE Verwandte Suche:

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