Endrin (ISO)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P262：Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

ENDRIN Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  WEISSE KRISTALLE.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen über 245°C unter Bildung von Chlorwasserstoffund Phosgen.

• ARBEITSPLATZGRENZWERTE

  TLV: 0,1 mg/m?(als TWA); Hautresorption; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2008).
  MAK: 0,1 mg/m?Spitzenbegrenzung: überschreitungsfaktor II(8); Hautresorption; Schwangerschaft: Gruppe C; (DFG 2008).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgenden Krämpfen und Tod. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.

• LECKAGE

  NICHT in die Kanalisation spülen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R24:Giftig bei Berührung mit der Haut.
  R28:Sehr giftig beim Verschlucken.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
  R38:Reizt die Haut.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.
  S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
  S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.

• Chemische Eigenschaften

  Endrin is the common name of one member of the cyclodiene group of pesticides. It is a cyclic hydrocarbon having a chlorine-substituted, methano-bridge structure. Endrin is a white, crystalline solid

• Chemische Eigenschaften

  Endrin is an organochlorine compound. Endrin appears as a stable, white or beige crystalline solid. It is incompatible with strong acids and strong oxidizers and corrodes some metals.Endrin decomposes on heating above 245°C producing hydrogen chloride, phosgene. In fact, the US EPA has sharply restricted the availability and uses of many organochlorine groups of pesticides. These include DDT, aldrin, dieldrin, endrin, heptachlor, mirex, chlordecone, and chlordane, while many other organochlorines, however, remain the active ingredients of various home and garden products and some agricultural, structural, and environmental pest control products.

• Chemische Eigenschaften

  Endrin is an organochlorine compound. Endrin appears as a white or beige crystalline solid and is stable. It is incompatible with strong acids and strong oxidisers and corrodes some metals. Endrin decomposes on heating above 245°C, producing hydrogen chloride and phosgene. Endrin is incompatible with strong oxidisers, strong acids, and parathion and emits hydrogen chloride and phosgene when heated or burned.

• Physikalische Eigenschaften

  White, crystalline solid when pure; light tan color with faint chemical odor for technical grades. Odor threshold concentrations in air ranged from 18 to 41 ppb (quoted, Keith and Walters, 1992). Robeck et al. (1965) reported an odor threshold concentration of 9 ppb.

• Verwenden

  All uses of endrin in the United States were canceled by the manufacturer in 1986; formerly used as an insecticide, avicide, and rodenticide

• Verwenden

  Formerly as insecticide.

• Definition

  A stereoisomer of dieldrin which is the endo, exo isomer.

• Allgemeine Beschreibung

  ENDRIN is a white crystalline, odorless solid dissolved in a liquid carrier. ENDRIN is water emulsifiable. ENDRIN is toxic by inhalation, skin absorption, and/or ingestion. When heated or burned ENDRIN may emit toxic hydrogen chloride and phosgene. ENDRIN is used as a pesticide.

• Reaktivität anzeigen

  While a mixture of parathion and ENDRIN was being blended into a petroleum solvent, an exothermic reaction occurred that caused some of the petroleum solvent to vaporize. The solvent-vapor-air mixture exploded. The mechanical agitation possibly initiated the exothermic reaction, Doyle(1973). Toxic hydrogen chloride and phosgene may be generated when solution burns. Avoid strong oxidizers, strong acids and parathion. [EPA, 1998].

• Hazard

  Toxic by inhalation and skin absorption, use may be restricted. Headache, liver damage, and central nervous system impairment. Questionable carcinogen.

• Health Hazard

  ENDRIN is extremely toxic. It is rapidly absorbed through the skin. Symptoms appear between 20 minutes and 12 hours after exposure. There is evidence that ENDRIN may cause chromosomal damage. Doses of 1 mg/kg can cause symptoms. It is a suspected carcinogen. Also, it is a central nervous system depressant and hepatotoxin. Pregnant women are considered to be at special risk.

• Health Hazard

  Extremely toxic to experimental animals byall routes of exposure; also, highly toxic tohumans and animals by ingestion or skinabsorption; toxic effects similar to those ofaldrin and dieldrin; symptoms — headache,dizziness, nausea, vomiting, abdominal pain,insomnia, confusion, stupor, convulsions,tremors, rise in blood pressure, fever, frothing of mouth, deafness, coma, and respiratoryfailure; stimulant to central nervous system;ingestion of 50–60 mg can produce toxicsymptoms in human; can produce adversereproductive effects; a teratogenic substance;evidence of carcinogenicity in experimental animals and humans inadequate; oralLD50 value (mice): ～13 mg/kg, (guinea pig):16 mg/kg; U.S. EPA listed extremely hazardous substance; exposure limit: PEL/TLV TWA(skin) 0.1 mg/kg (OSHA, ACGIH).

• Health Hazard

  Exposures to endrin cause toxicity and adverse health effects. Endrin is highly toxic to humans and species of animal. The symptoms of poisoning include, but are not limited to, headache, dizziness, nausea, vomiting, incoordination, tremor, mental confusion, and hyperexcitable state. Exposures to very high concentrations of endrin and in severe cases of poisoning, symptoms include convulsions, seizures, coma, and respiratory depression. In severe organochlorine compound poisoning, symptoms include myoclonic jerking movements, generalized tonic-clonic convulsions, respiratory depression following the seizures, and coma.

• Brandgefahr

  Toxic hydrogen chloride and phosgene may be generated when solution burns. Avoid strong oxidizers, strong acids and parathion.

• Landwirtschaftliche Anwendung

  Insecticide, Avicide: Not approved for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP). It is a persistent and acutely toxic insecticide. Endrin is an insecticide which has been used to control insects, rodents, and birds, mainly on field crops such as cotton, maize, sugarcane, rice, cereals, ornamentals, and other crops. It has also been used for grasshoppers in non-cropland and to control voles and mice in orchards. Once widely used in the U.S., most uses were canceled in 1980 and it has not been produced nor sold in the U.S. since 1986. It is not easily dissolved in water and can remain in the soil for more than 14 years.

• Handelsname

  COMPOUND 269®; EN 57®; ENDREX®; ENDRICOL®; ENDRIN CHLORINATED HYDROCARBON INSECTICIDE®; HEXADRIN®; MENDRIN®; NENDRIN®; OKTANEX®

• Sicherheitsprofil

  Poison by ingestion, skin contact, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen. Mutation data reported. A central nervous system stimulant. Highly toxic to birds, fish, and humans. Many cases of fatal poisoning have been attributed to it. Does not accumulate in human tissue. In humans, ingestion of 1 mg/kg has caused symptoms. A dangerous fire hazard. Mixtures with parahon dlssolve very exothermically in petroleum solvents and may cause an air-vapor explosion. See also ALDFUN.

• mögliche Exposition

  A potential danger to those involved in manufacture, formulation and field application of this insecticide, avicide, and rodenticide. Pesticide not in use; TRI and/ or IUR indicates importers or manufacturers are unlikely.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing materialfrom skin is of extreme importance. Shampoo hairpromptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit

• Environmental Fate

  Biological. In four successive 7-day incubation periods, endrin (5 and 10 mg/L) was recalcitrant to degradation in a settled domestic wastewater inoculum (Tabak et al., 1981). Soil. Microbial degradation of endrin in soil formed several ketones and aldehydes of which keto-endrin was the only metabolite identified (Kearney and Kaufman, 1976). In eight Indian rice soils, endrin degraded rapidly to low concentrations after 55 days. Degradation was highest in a pokkali soil and lowest in a sandy soil (Gowda and Sethunathan, 1976).
  Under laboratory conditions, endrin degraded to other compounds in a variety of soils maintained at 45°C. Except for Rutledge sand, endrin disappeared or was transformed in the following soils after 24 hours: Lynchburg loamy sand, Magnolia sandy loam, Magnolia sandy clay loam, Greenville sandy clay and Susquehanna sandy clay. No products were identified (Bowman et al., 1965).
  The disappearance half-lives for endrin in field soils under flooded and nonflooded conditions were 130 and 468 days, respectively (Guenzi et al., 1971). The average disappearance half-life in flooded soils under laboratory conditions was 31 days (Gowda and Sethunathan, 1976, 1977).
  The percentage of endrin remaining in a Congaree sandy loam soil after 14 years was 41% (Nash and Woolson, 1967).
  Groundwater. According to the U.S. EPA (1986) endrin has a high potential to leach to groundwater.
  Plant. In plants, endrin is converted to the corresponding sulfate (Hartley and Kidd, 1987).
  Surface Water. Algae isolated from a stagnant fish pond degraded 24.4% of the applied endrin to ketoendrin (Patil et al., 1972).
  Photolytic. Photolysis of thin films of solid endrin using UV light (l = 254 nm) produced d-ketoendrin, endrin aldehyde and other compounds (Rosen et al., 1966). Endrin exposed to a hot California sun for 17 days completely isomerized to d-ketoendrin or 1,8- exo-9,10,11,11-hexachlorocyclo[6.2.1.13,6.02,7.04,10]dodecan-5-one (Burton and Pollard, 1974). Irradiation of endrin by UV light (l = 253.7 nm and 300 nm) or by natural sunlight in cyclohexane and n-hexane solution resulted in an 80% yield of 1,8-exo-9,11,11-pentachloropentacyclo[ 6.2.1.13,6.02,7.04,10]dodecan-5-one (Zabik et al., 1971). When an aqueous solution containing endrin was photooxidized by UV light at 90–95°C, 25, 50 and 75% degraded to carbon dioxide after 15.0, 41.0 and 172.0 hours, respectively (Knoevenagel and Himmelreich, 1976).
  Chemical/Physical. At 230°C, endrin isomerizes to an aldehyde and a ketone. When heated to decomposition, hydrogen chloride and phosgene may be released (NIOSH, 1994) but residues containing an aldehyde (15–20%), a ketone (55–60%), a caged alcohol (5%), and other volatile products (15–20%) were reported (Phillips et al., 1962).
  In water, endrin will undergo nucleophilic attack at the epoxide moiety forming endrin diol (Kollig, 1993).
  At 50°C, endrin was not unaffected by the oxidants chlorine, permanganate and persulfate (Leigh, 1969).

• Solubility in organics

  At 25 °C: acetone (170 g/L), benzene (138 g/L), carbon tetrachloride (33 g/L), hexane (71 g/L), xylene (183 g/L) (Windholz et al., 1983). Soluble in aromatic hydrocarbons, esters, and ketones (ITII, 1986).

• Solubility in water

  At 25 °C: acetone (170 g/L), benzene (138 g/L), carbon tetrachloride (33 g/L), hexane (71 g/L), xylene (183 g/L) (Windholz et al., 1983). Soluble in aromatic hydrocarbons, esters, and ketones (ITII, 1986).

• Versand/Shipping

  UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

• Toxicity evaluation

  Endrin (40) is 1,2,3,4,10,10-hexachloro- 1,4,4a,5,8,8a-hexahydro-6,7-epoxy-1,4-endo,endo- 5,8-dimethanonaphthalene (mp 245 dec, vp 0.022 mPa at 25 ?C) and is soluble in water to 23 μg/L. This compound is the endo,endo isomer of dieldrin, which is less stable and more toxic than dieldrin with rat LD₅₀ values of 17.8 and 7.5 (oral) and 15 (dermal) mg/kg. It was used as a cotton insecticide, but because of its high toxicity to fish, its use was restricted.

• Inkompatibilitäten

  Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids (forms explosive vapors), oxoacids, epoxides, and parathion. Slightly corrosive to metal

• Waste disposal

  A disposal procedure recommended by the manufacturer consists of absorption, if necessary, and burial at least 18 in deep; preferably in sandy soil in a flat or depressed location away from wells, livestock, children, wildlife, etc. Incineration is the recommended method. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

• Vorsichtsmaßnahmen

  Students and occupational workers should be careful during handling of endrin. Workers should not wash away the chemical waste into the sewer, but sweep spilled chemical substance into sealable containers. Workers should use extra personal protection, face shield and eye protection, a chemical protection suit, and self-contained breathing apparatus. Exposures to endrin cause effects on the CNS leading

72-20-8, ENDRIN Verwandte Suche: