SL 327

Bezeichnung:SL 327

CAS-Nr305350-87-2

Englisch Name:SL 327

CBNumberCB4168773

SummenformelC16H12F3N3S

Molgewicht335.35

MOL-Datei305350-87-2.mol

SL 327 physikalisch-chemischer Eigenschaften

Schmelzpunkt	127-128.2 °C
Siedepunkt	512.6±50.0 °C(Predicted)
Dichte	1.40
storage temp.	2-8°C
Löslichkeit	DMSO: 32 mg/mL
Aggregatzustand	solid
pka	3.42±0.10(Predicted)
Farbe	white

Sicherheit

WGK Germany	3
HS Code	2930909899

Gefahreninformationscode (GHS)

SL 327 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC₅₀s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC₅₀s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.
Verwenden
SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.
Definition
ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4 aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Biologische Aktivität
Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Biochem/physiol Actions
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
Lager
+4°C (desiccate)

SL 327 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

305350-87-2, SL 327 Verwandte Suche:

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