2-Amino-4-chloro-6-phenylpyrimidine

2-Amino-4-chloro-6-phenylpyrimidine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  56-05-3

  

  98-80-6

  

  36314-97-3

  Example 2 Preparation of Compound 2 Step A - Synthesis of Compound 2b: To a reaction flask was added 2-amino-4,6-dichloropyrimidine (2.0 g, 12.2 mmol), acetonitrile (40 mL), potassium carbonate (2M aqueous solution, 6.1 mL, 12.2 mmol), tetrakis(triphenylphosphine)palladium (0.35 g, 0.31 mmol), and phenylboronic acid (0.74 g 6.1 mmol). The reaction mixture was stirred and heated to 90 °C and kept for 4 hours. After completion of the reaction, it was cooled to room temperature, transferred to a partition funnel, dichloromethane (50 mL) and water (50 mL) were added and mixed thoroughly to separate the organic layer. The aqueous layer was extracted with dichloromethane, the organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. Purification by preparative thin layer chromatography (unfolding agent: 100% dichloromethane) afforded 2-amino-4-chloro-6-phenylpyrimidine (0.8 g, 64% yield).

• Einzelnachweise

  [1] Patent: WO2009/111449, 2009, A1. Location in patent: Page/Page column 38-39
  [2] Patent: WO2015/187089, 2015, A1. Location in patent: Page/Page column 65
  [3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2303 - 2308
  [4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 16, p. 3670 - 3674
  [5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 8, p. 2497 - 2501

2-Amino-4-chloro-6-phenylpyrimidine Upstream-Materialien And Downstream Produkte

2-Amino-4-chloro-6-phenylpyrimidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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