Aganodine

Aganodine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Aganodine ,ZYF Pharm Chemical

• Manufacturing Process

  The solution of 3,6-dichlorophthalic anhydride in 300 ml of N,Ndimethylformamide are heated to the boiling point over 15 min with tbutylcarbazate. Subsequent to evaporation of the solvent, N-(tbutyloxycarbonylamino)- 3,6-dichlorophthalimide is obtained from ethanol.
  The solution of N-(t-butyloxycarbonylamino)-3,6-dichlorophthalimide in 400 ml of absolute tetrahydrofuran are slowly dripped into a suspension of aluminum lithium hydride in absolute tetrahydrofuran. The mixture is heated to the boiling point. Conventional processing yields N-(t-butyloxycarbonylamino)-4,7- dichloroisoindoline.
  N-(t-Butyloxycarbonylamino)-4,7-dichloroisoindoline are introduced into concentrated hydrochloric acid and stirred at room temperature. The hydrochloride of 2-amino-4,7-dichloroisoindoline precipitates in the form of crystals is obtained, melting point 230°-232°C.
  2-Amino-4,7-dichloroisoindoline hydrochloride and cyanamide are heated over 2 h to the boiling point in n-amyl alcohol. The solvent is evaporated off and the residue recrystallized from isopropyl alcohol and ethyl ether, yielding the (4,7-dichloroisoindolin-2-yl)guanidine in the form of hydrochloride, melting point 235°-237°C.
  To obtained the base (4,7-dichloroisoindolin-2-yl)guanidine the salt (4,7- dichloroisoindolin-2-yl)guanidine hydrochloride is treated with sodium bicarbonicum.

• Therapeutic Function

  Antihypertensive

Aganodine Upstream-Materialien And Downstream Produkte

Aganodine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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