(-)-ANABASINE

Bezeichnung:(-)-ANABASINE

CAS-Nr13078-04-1

Englisch Name:(-)-ANABASINE

CBNumberCB4100643

SummenformelC10H14N2

Molgewicht162.23

MOL-Datei13078-04-1.mol

(-)-ANABASINE physikalisch-chemischer Eigenschaften

Schmelzpunkt	9 °C
Siedepunkt	270 °C
Dichte	1.05 g/mL at 25 °C(lit.)
Brechungsindex	1.5440
Flammpunkt	93 °C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	H₂O: 10 mg/mL
pka	8.98±0.10(Predicted)
Aggregatzustand	liquid
Farbe	colorless to yellow
Merck	14,619
BRN	82639
InChIKey	MTXSIJUGVMTTMU-UHFFFAOYSA-N
LogP	0.852 (est)

Sicherheit

Kennzeichnung gefährlicher	T,Xn
R-Sätze:	23/24/25-36/37/38-25-20/21/22-51/53-27/28
S-Sätze:	36/37/39-45-26-36-57-27/28-23-20
RIDADR	UN 3140 6.1/PG 2
WGK Germany	3
RTECS-Nr.	BV4375000
Hazard Note	Toxic
HazardClass	6.1
PackingGroup	I
HS Code	29339900

Gefahreninformationscode (GHS)

(-)-ANABASINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R25:Giftig beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Anatabine is an alkaloid found in the root, fibrous roots, or bark of Alangium chinense (Lour) Harms. The herb was recorded in “Jianyi Bencao,” “Bencao Gangmu Shiyi,” and “Zhi Wu Ming Shi Tu Kao.” Alangium chinense is widely distributed in the east and south of China. It is also called “Bailongxu” in Shaanxi, Yunnan, and Guizhou provinces, “Baijintiao” in Guangxi province, and “Bajiaowutong,” “Bajiaojinpan,” or “Laolongxu” in Jiangxi and Hubei provinces. This plant is commonly used as a traditional Chinese medicine. The Alangium species includes more than 30 plants which are distributed in Asia, Oceania, and Africa. Nine of these plants are distributed in China. The root and the stem parts of Alangium plants are toxic.
Chemische Eigenschaften
Colourless Oil
Physikalische Eigenschaften
Appearance: Colorless to yellow liquid. Solubility: Soluble in water and common organic solvents. Boiling point: 110?°C. Refractive index: 1.5418. Density: 1.0516?g cm?3.
History
Alangium chinense contains alkaloids, sugars, saponins, steroids, triterpenes, anthraquinones and their glycosides, and other ingredients. In 1974, dl-anabasine was isolated from the fibrous roots of Alangium chinense . Four isoquinoline alkaloids including two new alkaloids (?)-10-O-dimethyl-eugenol base and 10-O-dimethyl-eugenol base were isolated. P-amyrin acetate, triacontanol, and β-sitosterol were then found in its leaves . Seven glycosides were isolated from the water-soluble fraction of dried leaves of Alangium chinense, and eight glycosides were also isolated from the n-butanol soluble part . Three new lignincompounds including 2-O-(β-apio-furanosyl)-β-glucoside, E ferulic acid ester, and Z ferulic acid ester were extracted from Alangium chinense, and their structures were determined. Nakamoto et?al. extracted 7-O-acetylmaleic acid from Alangium chinense and determined the structure. There are also long-chain fatty acids and short-chain alkanes in Alangium chinense leaves. The volatile oil was then analyzed, and 59 components are identified by GC-MS.?The total alkaloid content in the Alangium chinense was found to be fibrous root > fine root > coarse root > branch wood > leaf.
Verwenden
A nicotinic receptor agonist
Verwenden
Anabasine, a tobacco alkaloid, was used as a biomarker of active tobacco use.
Verwenden
insecticide
Definition
ChEBI: A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.
Allgemeine Beschreibung
Anabasine inhibited androstenedione conversion to estrogen in a dose-dependent manner.
Pharmakologie
Alangium plants have wide pharmacological effects including muscle relaxation, central inhibition, anticancer, antibacterial, and so on. The “Jisong-II” injection has presynaptic and postsynaptic effects on the neuromuscular junction, and it acts as noncompetitive muscular relaxant . In 1979, the respiratory suppression experiments showed that Alangium chinense is a central nervous system depressant . The extract of Alangium chinense significantly inhibits the growth of P388 lymphoblastic leukemia and Gardner lymphosarcoma in mice, but it has no effect on Gross virus-induced leukemia, Warner myelomonocytic leukemia, and B16 melanoma . Another study reported that the anabasine could excite respiratory similar to nicotine and lobeline. Anabasine also induces high blood pressure and bradycardia. The components in the Alangium chinense extract can bind to the M, 5-HT and dopamine receptors indicating that Alangium chinense affects the central nervous system.
Clinical Use
The Alangium chinense was used for treating rheumatoid arthritis.

(-)-ANABASINE Upstream-Materialien And Downstream Produkte

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