iopronic acid Struktur

Ioproninsure

Bezeichnung:Ioproninsure

CAS-Nr37723-78-7

Englisch Name:iopronic acid

CBNumberCB3922729

SummenformelC15H18I3NO5

Molgewicht673.02

MOL-Datei37723-78-7.mol

Synonyma

Ioproninsure

Ioproninsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	130°C
Siedepunkt	674.2±55.0 °C(Predicted)
Dichte	2.0615 (estimate)
pka	4.28±0.10(Predicted)
Wasserlöslichkeit	20.08g/L(37 ºC)

iopronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Bilimiru,Bracco,Italy,1974
Verwenden
Diagnostic aid (radiopaque medium, cholecystographic).
Definition
ChEBI: Iopronic acid is an aromatic amide.
Manufacturing Process
,A solution of 192 g 3-acetylamino-2,4,6-triiodophenol, sodium (0.35 mol) in 350 ml dimethylacetamide, was mixed with 107.5 g 3-(2-iodoethoxy)-2- ethylpropionic acid ethyl ester (0.35 mol) at 90°C with stirring over a period of about 20 to 30 minutes. Stirring was continued while the mixture was held at 95°C to 100°C for 16 hours. The solvent was then removed by distillation in a vacuum, and the residue was poured into 4,000 ml water. The solid precipitate formed was recovered and washed with water, dilute sodium carbonate solution, dilute sodium bisulfite solution, and again with much water. The ethyl ester was obtained in a yield of 220 g (90%). When recrystallized from 75% aqueous ethanol, it melted at 80°C to 86°C.
The ester (70 g, 0.1 mol) was saponified in a boiling mixture of 250 ml methanol and 250 ml water to which 100 ml N sodium hydroxide solution was added in small batches with stirring. The methanol was distilled from the saponification mixture, the residue was mixed with water and extracted with ethyl acetate. The aqueous phase was acidified with hydrochloric acid in the presence of sodium bisulfite.
The free acid gradually crystallized from the acidified solution in the amount of42.4 g (63% yield). When recrystallized from 50% ethanol and from ethyl acetate, it melted at 130°C.
Trademarks
Bilimiro (Bracco Industria Chimica S.p.A., Italy); Bilimiron (Bracco Industria Chimica S.p.A., Italy); Oravue (Bristol-Myers Squibb); Videobil (Bracco Industria Chimica S.p.A., Italy).
Therapeutic Function
Diagnostic aid (radiopaque medium)

iopronic acid Upstream-Materialien And Downstream Produkte

Ioproninsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

37723-78-7, iopronic acid Verwandte Suche:

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