Debrisochin

debrisoquine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Declinax,Roche,UK,1967

• Verwenden

  Antihypertensive.

• Definition

  ChEBI: Debrisoquin is a member of isoquinolines and a carboxamidine. It has a role as an antihypertensive agent, an adrenergic agent, a sympatholytic agent and a human metabolite.

• Manufacturing Process

  27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The resulting mixture was kept at room temperature with occasional shaking. After a short period of time, methylmercaptan began to escape, and the mixture warmed up slightly. After then standing for 24 hours, crystals formed. They were filtered off and rinsed with ice cold water. Recrystallization from approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2- carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
  Another batch prepared in the same manner melted at 284°C to 285°C due to a minute difference in moisture content.
  Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.

• Trademarks

  Declinax (HoffmannLaRoche).

• Therapeutic Function

  Antihypertensive

debrisoquine Upstream-Materialien And Downstream Produkte

Debrisochin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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