tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid

tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Bufetolol,ZYF Pharm

• Definition

  ChEBI: Bufetolol hydrochloride is an aromatic ether.

• Manufacturing Process

  To a solution of 1 gramm equivalent (g-eq.) of 1-bromo-3-[2- (tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily 1-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2- propanol. The corresponding acid fumarate melts at 128°-132°C.

• Therapeutic Function

  Antiarrhythmic, Beta-adrenergic blocker

tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride Upstream-Materialien And Downstream Produkte

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