Mitobronitol

Bezeichnung:Mitobronitol

CAS-Nr488-41-5

Englisch Name:1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL

CBNumberCB3692682

SummenformelC6H12Br2O4

Molgewicht307.97

MOL-Datei488-41-5.mol

Synonyma

Mitobronitol

Mitobronitol physikalisch-chemischer Eigenschaften

Schmelzpunkt	176-178°
Siedepunkt	511.2±50.0 °C(Predicted)
Dichte	1.8987 (rough estimate)
Brechungsindex	1.4840 (estimate)
storage temp.	−20°C
pka	12.61±0.20(Predicted)
EPA chemische Informationen	Mitobronitol (488-41-5)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	45-22
S-Sätze:	53-22-36/37/39-45
WGK Germany	3
RTECS-Nr.	OP2800000

Gefahreninformationscode (GHS)

1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Myelobromol,Hormonchemie,W. Germany,1967
Verwenden
Antineoplastic.
Definition
ChEBI: Mitobronitol is an alcohol and an organobromine compound.
Manufacturing Process
750 g D-mannitol are dissolved in 4,000 ml of a 48% aqueous hydrogenbromide solution, whereupon the solution thus obtained is saturated at 0°Cwith gaseous hydrogen bromide until a HBr content of 69 to 70% is achieved.The reaction mixture is heated for 6 hours at 60°C in an autoclave, is thendecolorized with charcoal, extracted with 1 liter chloroform twice and dilutedwith 7 liters of water. The pH value of the solution is adjusted by means ofsodium bicarbonate to1 to 2. The crystals precipitated after cooling for a dayare filtered and washed with water until free from acid. 250 g crude 1,6-dibromo-1,6-didesoxy-D-mannitol are obtained. MP 176° to 178°C. Analysis:Br % = 52 (calc.: 51.9).
250 g of the crude DBM are dissolved in 2.5 liters of hot methanol and ondecolorizing and filtration 2.5 liters of dichloroethane are added. 220 g ofcrystalline DBM are obtained. MP 178°C. Br % = 51.9.
Therapeutic Function
Cancer chemotherapy
Allgemeine Beschreibung
White powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
A halogenated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Brandgefahr
Flash point data for 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL are not available, but 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL is probably combustible.

1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Upstream-Materialien And Downstream Produkte

Mitobronitol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

488-41-5, 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL Verwandte Suche:

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