FMOC-LYS(BOC)(ME)-OH

Bezeichnung:FMOC-LYS(BOC)(ME)-OH

CAS-Nr951695-85-5

Englisch Name:FMOC-LYS(BOC)(ME)-OH

CBNumberCB3465262

SummenformelC27H34N2O6

Molgewicht482.57

MOL-Datei951695-85-5.mol

FMOC-LYS(BOC)(ME)-OH physikalisch-chemischer Eigenschaften

Schmelzpunkt	85-87℃
Siedepunkt	665.4±55.0 °C(Predicted)
Dichte	1.200
storage temp.	-20°C
Löslichkeit	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Aggregatzustand	Powder
pka	3.88±0.21(Predicted)
InChIKey	JHMSFOFHTAYQLS-QHCPKHFHSA-N

Sicherheit

Kennzeichnung gefährlicher	Xi
WGK Germany	WGK 2 water endangering
HS Code	2924 29 70

Gefahreninformationscode (GHS)

FMOC-LYS(BOC)(ME)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fmoc-lys (BOC) (ME)-OH is a kind of protected form of lysine. Lysine is double-protected by butyloxycarbonyl (BOC) and 9H-fluoren-9-ylmethoxycarbon (FMOC). It is a derivative for the introduction of monomethyl-lysine during Fmoc SPPS. Coupling can be carried out using any standard activation method. The Boc protecting group can be removed through the TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.
Verwenden
1. Heterochromatin protein 1 (HP1) depends on trimethylation of H3 Lys 9; aggregation of chromatines depends on Lys methylation
2. Fmoc-Lys(Boc, Me)-OH is useful for preparing monomethylated histone fragments utilized in studying the regulatory roles of methylated histones. Fmoc-Lys(Boc,Me)-OH can be coupled using standard activating procedures. The Boc group on the side epsilon nitrogen atom is removed with TFA, usually at the same time as the peptide is cleaved from the resin.
3. Fmoc-Lys(Boc, Me)-OH is a novel derivative for the introduction of monomethyl-lysine during Fmoc SPPS. Coupling can be carried out using any standard activation method. Removal of the Boc protecting group occurs during the course of the TFA-mediated cleavage reaction.
Allgemeine Beschreibung
Fmoc protected N-methylated lysine
Einzelnachweise
http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid_Fmoc-Lys_Boc_Me_-OH.htm
https://en.wikipedia.org/wiki/Peptide_synthesis
Tung, C. L., et al. "A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation. " Chemical Communications 50.40(2014):5298-300.

FMOC-LYS(BOC)(ME)-OH Upstream-Materialien And Downstream Produkte

FMOC-LYS(BOC)(ME)-OH Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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