N,N'-Dimethyl-9,9'-bisacridiniumnitrat

Bezeichnung:N,N'-Dimethyl-9,9'-bisacridiniumnitrat

CAS-Nr2315-97-1

Englisch Name:LUCIGENIN

CBNumberCB3325847

SummenformelC28H22N4O6

Molgewicht510.5

MOL-Datei2315-97-1.mol

Synonyma

N,N'-Dimethyl-9,9'-bisacridiniumnitrat

N,N'-Dimethyl-9,9'-bisacridiniumnitrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	250°C
Löslichkeit	acetic acid: soluble10mg/mL
Aggregatzustand	powder
Farbe	Yellow powder with orange to brown cast
maximale Wellenlänge (λmax)	455nm
BRN	3901768
Biologische Anwendungen	Chloride indicator; diagnosis of hemostatic disorders; detecting bacteria,nucleicacids,proteins,pathogens; identifying respiratory infections; generating and detecting reactive oxygen species; chemiluminescent indicator
InChI	InChI=1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;22-1(3)4/h3-18H,1-2H3;;/q+2;2-1
InChIKey	KNJDBYZZKAZQNG-UHFFFAOYSA-N
SMILES	C1(=C2C=CC=CC2=[N+](C)C2=CC=CC=C12)C1=C2C=CC=CC2=[N+](C)C2=CC=CC=C12.[N+]([O-])([O-])=O.[N+]([O-])([O-])=O

Sicherheit

S-Sätze:	24/25
RIDADR	1479
WGK Germany	3
HazardClass	5.1
PackingGroup	III
HS Code	29339900

Gefahreninformationscode (GHS)

LUCIGENIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Lucigenin is a chemiluminescent probe used to detect superoxide production and the presence of chloride. It can be used to detect superoxide production by enzymatic and cellular sources. It is a sensitive method that has been applied to the monitoring of superoxide production from xanthine oxidase, microsomal NADPH cytochrome reductase, and NADPH oxidases of phagocytes, endothelial cells, fibroblasts, and smooth muscle cells of blood vessel walls. However, it produces similar chemiluminescence signals in isolated aortic and cardiac tissues from wild-type and Nox1-Nox2-Nox4 triple knockout mice, suggesting that it is not selective for NADPH-based ROS production. It also reacts with hydrogen peroxide without generating free radical intermediates and has been used to detect lipid hydroperoxide in oils. Lucigenin is also used as a fluorescent chloride-sensitive indicator, with its fluorescence being quenched by chloride (ex/em = 455/505 nm, respectively). Lucigenin fluorescence is insensitive to phosphate, sulfate, and nitrate.
Chemische Eigenschaften
Dark yellow powder
Verwenden
Chemiluminescent probe for the detection of peroxides in biological systems.
Verwenden
Lucigenine, is used as chemiluminescence. It exhibits a bluish-green fluorescence. Dyes and metabolites.
Mechanism of action
In the case of lucigenin it is first reduced to a cation radical. Then it reacts in its univalently reduced form with ROS to produce dioxetane, which breaks down to generate photons. These probes cannot measure the individual free radicals but measure global ROS levels in the sample. Luminescence signals are expressed in relative light units (RLU), a direct measure of free radicals produced.

N,N'-Dimethyl-9,9'-bisacridiniumnitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2315-97-1, LUCIGENIN Verwandte Suche:

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