SQ 22,536 Struktur

SQ 22,536

Bezeichnung:SQ 22,536

Englisch Name:SQ 22,536

CBNumberCB3289950

SummenformelC9H11N5O

Molgewicht205.22

SQ 22,536 physikalisch-chemischer Eigenschaften

Schmelzpunkt	160-161℃
Siedepunkt	474.8±55.0 °C(Predicted)
Dichte	1.70±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	H₂O: 21 mg/mL
Aggregatzustand	solid
pka	3.82±0.10(Predicted)
Farbe	white to off-white

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
HS Code	2934.99.9001

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
SQ 22,536 is an inhibitor of adenylyl cyclase with an IC₅₀ value of 13 μM for inhibition of prostaglandin E₁-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.
Verwenden
SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.
Definition
ChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.
Biologische Aktivität
Inhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets.
Biochem/physiol Actions
SQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.1 It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.2
Lager
Store at +4°C