3,4-DICHLOROISOCOUMARIN Struktur

3,4-Dichlorisocumarin

Bezeichnung:3,4-Dichlorisocumarin

CAS-Nr51050-59-0

Englisch Name:3,4-DICHLOROISOCOUMARIN

CBNumberCB3278415

SummenformelC9H4Cl2O2

Molgewicht215.03

MOL-Datei51050-59-0.mol

Synonyma

3,4-Dichlorisocumarin

3,4-Dichlorisocumarin physikalisch-chemischer Eigenschaften

Siedepunkt	304.7±42.0 °C(Predicted)
Dichte	1.53±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Soluble in DMF or DMSO at a concentration of 10mM
Aggregatzustand	White lyophilized solid
Farbe	White to off-white
BRN	6802625

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
HazardClass	6.1

Gefahreninformationscode (GHS)

3,4-DICHLOROISOCOUMARIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor. It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site. It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase.
Verwenden
Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.
Definition
ChEBI: 3,4-dichloroisocoumarin is a member of the class of isocoumarins that is isocoumarin substituted by chloro groups at positions 3 and 4. It is a serine protease inhibitor. It has a role as a geroprotector and a serine protease inhibitor. It is a member of isocoumarins and an organochlorine compound.
Allgemeine Beschreibung
A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 μM.
Biochem/physiol Actions
Product does not compete with ATP.

3,4-Dichlorisocumarin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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