Mosapride

Bezeichnung:Mosapride

CAS-Nr112885-41-3

Englisch Name:Mosapride

CBNumberCB3273304

SummenformelC21H25ClFN3O3

Molgewicht421.89

MOL-Datei112885-41-3.mol

Mosapride physikalisch-chemischer Eigenschaften

Schmelzpunkt	151-153°C
Siedepunkt	549.2±50.0 °C(Predicted)
Dichte	1.272±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	13.52±0.46(Predicted)
Farbe	White to Off-White
CAS Datenbank	112885-41-3(CAS DataBase Reference)

Mosapride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.
Chemische Eigenschaften
White to Off-White Crystalline Solid
Originator
Dainippon (Japan)
Verwenden
gastroprokinetic agent
Verwenden
A selective 5-HT4 receptor agonist. Gastroprokinetic.
Definition
ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.
Trademarks
Gasmotin
Hazard
A poison by ingestion.
Sicherheitsprofil
A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.

Mosapride Upstream-Materialien And Downstream Produkte

Mosapride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

112885-41-3, Mosapride Verwandte Suche:

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