API-2

Bezeichnung:API-2

CAS-Nr35943-35-2

Englisch Name:API-2

CBNumberCB3270000

SummenformelC13H16N6O4

Molgewicht320.3

MOL-Datei35943-35-2.mol

API-2 physikalisch-chemischer Eigenschaften

Schmelzpunkt	207 °C (decomp)
Siedepunkt	459.21°C (rough estimate)
Dichte	1.2633 (rough estimate)
Brechungsindex	1.7000 (estimate)
storage temp.	Store at RT
Löslichkeit	DMSO: >10mg/mL
Aggregatzustand	powder
pka	12.35±0.70(Predicted)
Farbe	tan
InChIKey	HOGVTUZUJGHKPL-HTVVRFAVSA-N

Sicherheit

WGK Germany	3
RTECS-Nr.	RY8455000

Gefahreninformationscode (GHS)

API-2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Solid
Verwenden
Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells¹. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)².
Verwenden
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Definition
ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.
Biologische Aktivität
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Biochem/physiol Actions
Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.
Lager
Store at RT

API-2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

35943-35-2, API-2 Verwandte Suche:

Send Inquriy