3-Hydroxyphthalic anhydride

Bezeichnung:3-Hydroxyphthalic anhydride

CAS-Nr37418-88-5

Englisch Name:3-Hydroxyphthalic anhydride

CBNumberCB3253702

SummenformelC8H4O4

Molgewicht164.12

MOL-Datei37418-88-5.mol

3-Hydroxyphthalic anhydride physikalisch-chemischer Eigenschaften

Schmelzpunkt	199-202 °C (lit.)
Siedepunkt	365.4±25.0 °C(Predicted)
Dichte	1.624±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Acetonitrile (Slightly), DMSO (Slightly)
Aggregatzustand	Powder
pka	6.25±0.20(Predicted)
Farbe	White to beige
BRN	135783
Stabilität	Hygroscopic
InChI	InChI=1S/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H
InChIKey	CCTOEAMRIIXGDJ-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C(O)=CC=C2)C(=O)O1
CAS Datenbank	37418-88-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	TI3300000
F	21
HS Code	29182900
Toxizität	mouse,LD50,intravenous,75mg/kg (75mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#08845,

Gefahreninformationscode (GHS)

3-Hydroxyphthalic anhydride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
3-Hydroxyphthalic anhydride: a valuable raw material for chemical industry and pharmaceutical research.
Phthalic anhydride derivatives have been applied as plasticizers and heat-resistant polymers in the chemical industry. One of its derivatives is the 3-hydroxyphthalic anhydride (3-HPA), which exhibits a hydroxyl group substituent in position 3. 3-Hydroxyphthalic anhydride can be used as raw material for heat-resistant resins such as epoxy resins, polyesters, polyimides, etc., or as raw material for physiologically active substances such as medicines and pesticides. It has been shown that 3-HPA can serve as a raw material to obtain drugs with potential applications, such as anticancer, antimicrobial and in treating diabetes, herpes, and HIV[1].
Chemische Eigenschaften
Beige powder
Verwenden
3-Hydroxyphthalic Anhydride is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Synthesis, p. 788, 1985 DOI: 10.1055/s-1985-31350
Synthese
In the presence of triethylamine, the 2-oxo-2, 5-dihydrofuran, and pivaloyl chloride reactions generate 2-valeryl oxo furans. The affixture with 2-valeryl oxo furans and maleic anhydride uses vitriolization, which thereby generates the method of 3-hydroxyl phthalic anhydride.
Einzelnachweise
[1] M. López-Ortega. “Standard enthalpies of formation of 3-hydroxyphthalic anhydride.” Revista Mexicana De Fisica (2022).

3-Hydroxyphthalic anhydride Upstream-Materialien And Downstream Produkte

3-Hydroxyphthalic anhydride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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