Heptachlor (ISO)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H351：Kann vermutlich Krebs verursachen.

  H373：Kann die Organe schädigen bei längerer oder wiederholter Exposition.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

HEPTACHLOR Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  WEISSE KRISTALLEODER HELLBRAUNER WACHSARTIGERFESTSTOFF MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen über 160°C unter Bildung giftiger Rauche mit Chlorwasserstoff. Reagiert mit starken Oxidationsmitteln. Greift Metall an.

• ARBEITSPLATZGRENZWERTE

  TLV: 0.05 mg/m?(als TWA); Hautresorption; Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
  MAK: 0.5 mg/m?(Einatembare Fraktion) Spitzenbegrenzung: überschreitungsfaktor II(2); Hautresorption; Krebserzeugend Kategorie 3B; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Stäube von Pulverkonzentraten, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Möglich sind Auswirkungen auf das Zentralnervensystem.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Möglich sind Auswirkungen auf die Leber. Möglicherweise krebserzeugend für den Menschen.

• LECKAGE

  NICHT in die Umwelt gelangen lassen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
  R33:Gefahr kumulativer Wirkungen.
  R40:Verdacht auf krebserzeugende Wirkung.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
  R38:Reizt die Haut.

• S-Sätze Betriebsanweisung:

  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.

• Beschreibung

  Heptachlor is a soft, white to light tan, waxy, non-combustible, crystalline solid with a camphor-like odour. Heptachlor is a member of the cyclodiene group of chlorinated insecticides (aldrin, dieldrin, endrin, chlordane, heptachlor, and endosulfan) and has a long history following World War II. It was registered as a commercial pesticide in 1952 for foliar, soil, and structure applications and for malarial control programmes; after 1960, it was used primarily in soil applications against agricultural pests and to a lesser extent against termites. Heptachlor is available commercially as a dust, a dust concentrate, an emulsifiable concentrate, a wettable powder, or in oil solutions. It is corrosive to metals and reacts with iron and rust to form hydrogen chloride gas. Heptachlor is incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides but is stable under normal temperatures and pressures. It may burn, but does not ignite readily. Heptachlor at high heat and temperature produces highly toxic, corrosive fumes of hydrogen chlorine gas and toxic oxides of carbon. An important metabolite of heptachlor is heptachlor epoxide which is an oxidation product formed from heptachlor by many plant and animal species. Heptachlor is almost insoluble in water but soluble in ether, acetone, benzene, and many other organic solvents.

• Chemische Eigenschaften

  Heptachlor is an organochlorine cyclodiene insecticide isolated from technical chlordane. It is available in the form of white crystals or a tan-colored waxy solid with a characteris- tic camphor-like or cedar-like odor. It is sparingly soluble or insoluble in water, but fairly soluble in acetone, benzene, ethanol, xylene, and other organic solvents. It is used for the control of termites, ants, and soil insects in cultivated and non-cultivated soils. Heptachlor epoxide is formed in nature when heptachlor is released into the environment and mixes with oxygen. Heptachlor epoxide remains in the soil for long periods of time. Heptachlor and heptachlor epoxide may also be present at numerous hazardous waste sites. Although the use of heptachlor is restricted, exposure to the general population does occur through the ingestion of contaminated food.

• Chemische Eigenschaften

  white crystalline solid

• Physikalische Eigenschaften

  Colorless to light tan, waxy or crystalline, nonflammable solid with a camphor-like odor

• Verwenden

  Heptachlor is used for the control of termites, ants, household insects and soil insects. It is also applied as a seed treatment, soil treatment or directly to foliage.

• Verwenden

  Insecticide for termite control.

• Verwenden

  Formerly as insecticide for control of cotton boll weevil.

• Definition

  ChEBI: A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domes ic situations.

• synthetische

  Heptachlor may be synthesized by reacting chlordene with N-bromosuccinimide to give the intermediate 1-bromochlordene followed by chlorination with hydrogen chloride in nitromethane in the presence of aluminum trichloride.

• Allgemeine Beschreibung

  HEPTACHLOR is a white to light tan waxy looking solid. Noncombustible. Insoluble in water. Can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Used as an insecticide.

• Air & Water Reaktionen

  Susceptible to epoxidation. Insoluble in water. Slowly losses hydrogen chloride in the presence of alkaline solution.

• Reaktivität anzeigen

  HEPTACHLOR is incompatible with strong alkalis. Corrosive to metals. Can react with iron and rust to form toxic gases. Can react vigorously with oxidizing materials. Susceptible to epoxidation . May be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

• Hazard

  Toxic by ingestion, inhalation, and skin absorption; use has been restricted and discontinued except for termite control. Possible carcinogen.

• Health Hazard

  Inhalation of dust causes irritability, tremors, and collapse. Ingestion causes nausea, vomiting, diarrhea, and irritation of the gastrointestinal tract. Contract with dust causes irritation of eyes and moderate irritation of skin.

• Health Hazard

  Exposures to heptachlor epoxide cause adverse health effects to animals and humans. Exposure to heptachlor is toxic by mouth, by skin contact, as well as by inhalation of dust from powder concentrates. Heptachlor acts as a CNS stimulant. Prolonged period of expo- sures to high concentrations of heptachlor cause headache, dizziness, nausea, vomiting, weakness, irritability, salivation, lethargy, respiration distress, muscle tremors, convul- sions, and paralysis. Severe cases of poisoning lead to respiratory failure and death. In fact, seizures and cortical excitability are the prime CNS symptoms following acute hepta- chlor exposure. The photoisomer of heptachlor (photoheptachlor) and the major metabo- lite of heptachlor, namely, heptachlor epoxide are more toxic than the parent compound. Heptachlor induces tremors, convulsions, paralysis, and hypothermia in rats and young calves. The poisoned animals showed muscle spasms in the head and neck region, convul- sive seizures, elevated body temperatures, and engorged brain blood vessels. Humans exposed to heptachlor in the home during termite control operations showed signs of neurotoxicity, i.e., irritability, salivation, lethargy, dizziness, labored respiration, muscle tremors, convulsions, and death due to respiratory failure. Heptachlor interfered with nerve transmission, caused hyperexcitation of the CNS, lethargy, incoordination, tremors, convulsions, stomach cramps or pain, leading to coma and death.

• Health Hazard

  Highly toxic to animals; toxic symptoms —tremors, convulsions, and liver necrosis; alsocauses blood dyscrasias; oral LD50 value(rats): 40 mg/kg; caused liver cancers inmice; no evidence of human carcinogenicity;RCRA Waste Number P059; exposure limit:TLV-TWA (skin) 0.5 mg/m³ (ACGIH).
  Exposure of laboratory animals to heptachlor has shown to alter the levels and function of dopamine transporter producing dopaminergic neurotoxin (Caudle et al.2005). In an earlier study Kirby et al. (2001)investigated neurotoxicity of heptachlor inmice treated by intraperitoneal injection threetimes in 2-week period at dose levels of3–100 mg/kg. Their studies indicated thatheptachlor exerted selective effects on striatal dopaminergic neurons and played arole in the etiology of idiopathic Parkinson’s disease..

• Brandgefahr

  Special Hazards of Combustion Products: Irritating hydrogen chloride fumes may form in fire.

• mögliche Exposition

  A griculturalChemical; Tumorigen， Mutagen; Reproductive Effector.Those involved in the manufacture, formulation, and appli-cation of this insecticide for control of cotton boll weevil.Registration of heptachlor-containing pesticides has beencanceled by the US EPA with the exception of its use fortermite control outside of dwellings by in-ground (subsur-face) insertion. Infants have been ex posed to heptachlor andheptachlor epoxide through mothers' milk, cows' milk, andcommercially prepared baby foods. It appears that infantsraised on mothers’ milk run a greater risk of ingestingheptachlor epoxide than if they were fed cows' milk and/orcommercially prepared baby food. Persons living and work-ing in or near heptachlor-treated areas have a particularlyhigh inhalation exposure potential. Heptachlor has beenfound in at least 206 of the 1 662 current or former EPANational Priorities List (NPL) sites. Heptachlor epoxide hasbeen found in at least 195 NPL sites.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irri gate immediately for at least15 min, occasionally lifting upper and lower lids. Seek med-ical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and induce :vomiting. Do not make an unconscious person vomit.Note to physician: For severepoisoning，do not useBAL .[British Anti-Lewisite， dimercaprol, dithiopropanol (C3HgOS2)] as it is contraindicated or ineffective in poisoningfrom iron.

• Environmental Fate

  Biological. Many soil microorganisms were found to oxidize heptachlor to heptachlor epoxide (Miles et al., 1969). In addition, hydrolysis produced hydroxychlordene with subsequent epoxidation yielding 1-hydroxy-2,3-epoxychlordene (Kearney and Kaufman, 1976). Heptachlor reacted with reduced hematin forming chlordene, which decomposed to hexachlorocyclopentadiene and cyclopentadiene (Baxter, 1990). In a model ecosystem containing plankton, Daphnia magna, mosquito larva (Culex pipiens quinquefasciatus), ?sh (Cambusia af?nis), alga (Oedogonium cardiacum) and snail (Physa sp.), heptachlor degraded to 1-hydroxychlordene, 1-hydroxy-2,3-epoxychlordene, hydroxychlordene epoxide, heptachlor epoxide and ?ve unidentified compounds (Lu et al., 1975). In foursuccessive 7-day incubation periods, heptachlor (5 and 10 mg/L) was recalcitrant to degradation in a settled domestic wastewater inoculum (Tabak et al., 1981). When heptachlor (10 ppm) in sewage sludge was incubated under anaerobic conditions at 53°C for 24 hours, complete degradation was achieved (Hill and McCarty, 1967).
  In a mixed bacterial culture under aerobic conditions, heptachlor was transformed to chlordene, 1-hydroxychlordene, heptachlor epoxide and chlordene epoxide in low yields (Miles et al., 1971). Heptachlor rapidly degraded when incubated with acclimated, mi
  Soil. Heptachlor reacted with reduced hematin forming chlordene which decomposed to hexachlorocyclopentadiene and cyclopentadiene (Baxter, 1990). The reported half-life in soil is 9–10 months (Hartley and Kidd, 1987).
  Heptachlor was rapidly converted to 1-hydroxychlordene in eight dry soils having low moisture contents. Under these conditions, heptachlor epoxide was not identified (Bowman et al., 1965).
  Following application to an Ohio soil, only 7% of the applied amount had volatilized after 170 days (Glotfelty et al., 1984). Harris (1969) concluded that heptachlor has a very low tendency to leach in soils.

• Stoffwechselwegen

  Heptachlor is quite stable and resistant to environmental degradation. Metabolic processes by which it undergoes transformation are epoxidation, hydrolysis and dechlorination. It is transformed into a variety of products, many of which differ from one another only in stereochemical features while retaining the carbon skeleton and the chlorinated norbornene moiety. The main biological metabolite is exoepoxyheptachlor. Products formed by sensitised photolysis have caged structures and undergo reactions that are typical of this class.

• Solubility in organics

  At 27 °C (g/L): acetone (750), benzene (1,060), carbon tetrachloride (1,120), cyclohexanone (1,190), alcohol (45), xylene (1,020) (Windholz et al., 1983). Soluble in ether, kerosene, and ligroin (U.S. EPA, 1985).

• Solubility in water

  At 27 °C (g/L): acetone (750), benzene (1,060), carbon tetrachloride (1,120), cyclohexanone (1,190), alcohol (45), xylene (1,020) (Windholz et al., 1983). Soluble in ether, kerosene, and ligroin (U.S. EPA, 1985).

• Lager

  Color Code- Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, well-ventilated area. Protect storage containers from physicaldamage. Where possible, automatically pump liquid fromdrums or other storage containers to process containers. Aregulated, marked area should be established where thischemical is handled, used, or stored in compliance withOSHA Standard 1910.1045.

• Versand/Shipping

  Heptachlor (organochloride pesticides， solid,toxic, n.0.s.) requires a shipping label of “POISONOUS/TOXIC MATERIALS.”It falls in Hazard Class 6.1 andPacking Group II.

• Toxicity evaluation

  The primary target for heptachlor and the other cyclodiene insecticides is the central nervous system. The mode of action as a noncompetitive antagonist acting on the chloride ion channel of the γ aminobutyric acid (GABAA) receptor became evident more than 30 years after the discovery of heptachlor. When activated by GABA, the GABAA receptor increases Cl- conductance into the neurons and prevents excessive nerve stimulation. Heptachlor interferes with the passage of Cl- ions by binding to the Cl- channel of the receptor and thereby blocking the actions of GABA. Seizures, vomiting, and convulsions are typical symptoms associated with antagonism with GABA. Molecular modeling indicates that heptachlor epoxide also blocks the brain GABA-gated chloride channels. Heptachlor is implicated in causing long-lasting changes in brain functions, possibly by altering the expression of GABAA receptor during the mammalian development.
  Liver is another target of heptachlor toxicity (hepatocytomegaly, necrosis, steatosis, and tumors). However, the mechanism is unknown. Heptachlor induces hepatic cytochrome P-450 enzymes. In rat hepatocytes and mouse hepatoma cells, heptachlor and heptachlor epoxide initiated signal transduction processes characteristic for known mitogens, i.e., alteration of cellular Ca2+ levels and induction protein kinase C and mitogen-activated protein kinases. In mice, heptachlor epoxide causes downregulation of protein kinase C in the liver and induces the activator protein-1 DNA binding, both are critical factors in tumor promotion.

• Degradation

  Heptachlor (1) is stable in daylight, air, moisture and moderate heat (up to 160 °C). It is not readily dehydrochlorinated but it is susceptible to epoxidation. It is hydrolysed in water to 1-hydroxychlordene (5).
  Irradiation in hexane or cyclohexane at 253.7 nm gave two isomeric monodechlorination products (2 and 3). In acetone, the sole product was a compound with a cage structure (4) (Zabik et aE., 1970). In mixtures of cyclohexane and acetone, smaller quantities of 4 were obtained and the major product 6 was formed in which a chlorine atom has been replaced by a cyclohexyl moiety. The conversion of 1 into 4 by irradiation in acetone is parallelled by the acetone-sensitised photoreactions of chlordene, β-chlordane, chlordane, and β-dihydroheptachlor which also form analogous cage structures. Under these conditions, heptachlor epoxide (7) formed caged structures containing a ketonic group (9 and 10) (Fischler and Korte, 1969).
  A ketonic photoproduct (8), isomeric with heptachlor epoxide, was obtained when 1 was exposed to light of wavelengths >280 nm in acetone solution or on bean plants. Compounds 9 and 10 were also isolated from the reaction mixture and these were also produced by irradiation of compound 8, indicating that it is an intermediate in the photochemical reaction (Ivie et al., 1972).

• Inkompatibilitäten

  Reacts with strong oxidizers. Attacksmetal .Forms hydrogen chloride gas withiron and rustabove 74℃.

HEPTACHLOR Upstream-Materialien And Downstream Produkte

76-44-8, HEPTACHLOR Verwandte Suche: