Parsalmid

parsalmide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Parsalmide,Shanghai Lansheng Corporation

• Definition

  ChEBI: Parsalmide is a member of benzamides.

• Manufacturing Process

  5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
  5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the presence of sodium hydroxide
  5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
  28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.

• Therapeutic Function

  Muscle relaxant, Antiinflammatory, Analgesic

parsalmide Upstream-Materialien And Downstream Produkte

Parsalmid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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