4-Hydroxy-alpha-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-2-oxo-2H-1-benzopyran-3-essigsäure-ethylester

Ethyl Biscoumacetate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White, crystalline solid; odorless; bitter taste.Soluble in acetone and benzene; slightly soluble in alcohol and ether; insoluble in water.

• Originator

  Tromexan,Geigy,US,1950

• Verwenden

  Anticoagulant.

• Verwenden

  Medicine (anticoagulant).

• Definition

  A synthetic derivative of bishydroxycoumarin.

• Manufacturing Process

  7 g of benzotetronic acid are dissolved in 750 cc of water at boiling temperature and there after 10.5 g of glyoxylic acid ethyl ester ethyl alcoholate are added. After a short while the liquid becomes turbid and gradually a white deposit is separated. The deposit is filtrated and dried in vacuo. The melting point is 172°C to 174°C; after recrystallization from methyl alcohol 153°C to 154°C.
  The crude product is dissolved in sodium lye, filtrated by means of animal charcoal precipitated by means of hydrochloric acid, and recrystallized from methyl alcohol. The melting point is 153°C to 154°C.

• Therapeutic Function

  Anticoagulant

• Synthese

  Ethyl biscoumacetate, the ethyl ester of bis-(4-hydroxy- 3-coumarinyl)-acetic acid (24.1.9), is synthesized analogously from 4-hydroxycoumarine, but using ethylglyoxylate, its semiacetal or glyoxylic acid instead of formaldehyde.

  

Ethyl Biscoumacetate Upstream-Materialien And Downstream Produkte

4-Hydroxy-alpha-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-2-oxo-2H-1-benzopyran-3-essigsäure-ethylester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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