Trimethylphosphat

Bezeichnung:Trimethylphosphat

CAS-Nr512-56-1

Englisch Name:Trimethyl phosphate

CBNumberCB2853709

SummenformelC3H9O4P

Molgewicht140.07

MOL-Datei512-56-1.mol

Synonyma

Trimethylphosphat

Phosphors?uretrimethylester

Trimethylorthophosphat

Trimethylphosphat physikalisch-chemischer Eigenschaften

Schmelzpunkt	-46 °C (lit.)
Siedepunkt	197 °C (lit.)
Dichte	1.197 g/mL at 25 °C (lit.)
Dampfdruck	1.133 hPa (25 °C)
Brechungsindex	n20/D 1.395(lit.)
Flammpunkt	107 °C
storage temp.	Store below +30°C.
Löslichkeit	1000g/l
Aggregatzustand	Liquid
Wichte	1.197
Farbe	Clear
Wasserlöslichkeit	500 G/L (25 ºC)
Sensitive	Moisture Sensitive
BRN	1071731
Dielectric constant	21.260000000000002
InChIKey	WVLBCYQITXONBZ-UHFFFAOYSA-N
LogP	-0.46 at 25℃
CAS Datenbank	512-56-1(CAS DataBase Reference)
NIST chemische Informationen	Phosphoric acid, trimethyl ester(512-56-1)
EPA chemische Informationen	Trimethyl phosphate (512-56-1)

Sicherheit

Kennzeichnung gefährlicher	T,Xn,Xi
R-Sätze:	46-22-40-68-45-20/21/22-38-36
S-Sätze:	53-36/37-45-36/37/39-26
RIDADR	2810
WGK Germany	1
RTECS-Nr.	TC8225000
F	21
Hazard Note	Toxic/Moisture Sensitive
TSCA	Yes
HS Code	2919 90 00
Giftige Stoffe Daten	512-56-1(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: 840 mg/kg LD50 dermal Rabbit 3388 mg/kg

Gefahreninformationscode (GHS)

Trimethyl phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Phosphoroxiden. Reagiert mit starken Basen und starken Oxidationsmitteln. Kann beim Erhitzen bei Atmosphärendruck-Destillation über einen weiten Bereich explodieren.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK: Hautresorption; Krebserzeugend Kategorie 3B; Keimzellmutagen Kategorie 2; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf das Nervensystem.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglich sind Auswirkungen auf das Nervensystem mit nachfolgender Lähmung. Kann zu vererbbaren genetischen Schäden an menschlichen Keimzellen führen.
LECKAGE
Belüftung. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R46:Kann vererbbare Schäden verursachen.
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R68:Irreversibler Schaden möglich.
R45:Kann Krebs erzeugen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Trimethyl phosphate (TMP), the simplest trialkyl ester of phosphoric acid, It is a colourless, nonvolatile liquid. soluble in most organic solvents, low solubility in water. TMP is stable in neutral, acidic or alkaline solutions, and is classified as "not readily biodegradable". Direct photodegradation is not expected because trimethyl phosphate does not absorb UV light.
Verwenden
Trimethyl phosphate is used as an intermediate in organic synthesis. Its industrial applications are much fewer than those of other organic phosphates.Trimethyl phosphate undergoes hydrolysis in contact with water, so it should be stored in a moisture-proof manner. Due to its hydrolysis and release of PO43-, thus becoming a homogeneous precipitant for the formation of insoluble phosphate precipitation, often used as a precipitation reagent for zirconium and hafnium and as a diffusion source for the determination of semiconductors. In addition, trimethyl phosphate is also a phospholipid extractant for the extraction and separation of certain metal ions.
Verwenden
Trimethyl Phosphate is used as an electrolyte additive in the synthesis of lithium ion batteries. for controlling spark plug fouling, surface ignition and rumble in gasoline engines.
Trimethyl phosphate used as a reagent for determination of zirconium, solvent, extractant and gas chromatography stationary phase.
Vorbereitung Methode
Trimethyl phosphate is prepared by treating phosphorus oxychloride with methanol in the presence of an amine base:
POCl3 + 3 CH3OH + 3 R3N → PO(OCH3)3 + 3 R3NH+Cl
It is a tetrahedral molecule that is a weakly polar solvent.
Definition
ChEBI: Trimethyl phosphate is a trialkyl phosphate that is the trimethyl ester of phosphoric acid. It has a role as an insect attractant.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 3178, 1974 DOI: 10.1021/jo00935a041
Tetrahedron Letters, 28, p. 2981, 1987 DOI: 10.1016/S0040-4039(00)96262-2
Allgemeine Beschreibung
Trimethyl phosphate appears as a pale straw colored liquid. Inhalation may irritate respiratory tract. Vapor or liquid may irritate skin or eyes. Ingestion may irritate the mucous membranes of the gastrointestinal tract.
Reaktivität anzeigen
TRIMETHYL PHOSPHATE may explode when heated. Residue from a large scale atmospheric pressure distillation of Trimethyl phosphate has exploded violently. Trimethyl phosphate is incompatible with nitrates. . Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
Toxic by ingestion and inhalation, strong irritant to skin and eyes. trimethyl phosphate (TMP) is absorbed rapidly and completely by inhalation of its vapour, through the skin and by ingestion (WHO).
Health Hazard
Trimethyl phosphate (TMP) is a mutagen, teratogen, and a cancercausing compound. The health hazard from this compound is somewhat different from those of the higher members of the organic phosphate series. While carcinogenicity is observed only for this phosphate, with mutagenicity and the teratogenic effects being more marked, higher alkyl phosphates are more neurotoxic but noncarcinogenic.
TMP is toxic at high dosages.LD50 value,oral(mice):1470 mg/kg(NIOSH 1986)
Laboratory tests on animals indicated clear evidence of its cancer-causing actions, producing uterine and skin tumors. There is so far no report on such carcinogenic actions in humans. The compound tested positive in mutagenic tests and caused fetal deaths and birth defects in mice, rats, and hamsters when given orally or intraperitoneally.
Brandgefahr
Trimethyl phosphate is nonflammable.
Flammability and Explosibility
Not classified
Industrielle Verwendung
1 Gasoline additive at 0.25 g/gal for controlling surface ignition and spark plug fouling.
2 Methylating agent, chemical intermediate in the production of polymethyl polyphosphates.
3 Flame retardant solvent for paints and polymers.
4 Catalyst in the preparation of polymers and resins.
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, skin contact, intraperitoneal, and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes when heat distilled. When heated to decomposition it emits toxic fumes of POx. See also ESTERS.
Stoffwechsel
A system utilizing isolated anterior forearm stratum corneum conjunctum of man to study skin penetrating capacity of a series of organic phosphates was developed. Trimethyl phosphate was tested in the system and had the greatest skin-penetrating capacity of the 8 related compounds tested (Marzulli et al 1965).
Rats treated orally at 100 mg/kg and mice treated i.p. at 1000 mg/kg with [³²]P-labeled trimethyl phosphate excreted primarily dimethyl phosphate in the urine. Only traces of the parent compound were detected, and only in the rats at less than 6 h after treatment. S-Methyl cysteine and S-methyl cysteine N-acetate were also isolated. Small amounts of S-methyl glutathione were detected, presumably the initial methylation product in this series of metabolites (Jones 1970). Metabolism of trimethyl phosphate was faster in the mouse than in the rat, but there was no evidence of further conversion to monomethyl phosphate or inorganic phosphate in either species (Jackson and Jones 1968).
läuterung methode
Purify the phosphate by fractionation through an efficient column at high reflux ratio. It is quite soluble in H2O; the solubility is 1:1 at 25o. [Becker J Am Chem Soc 74 2923 1952, IR: Bergmann et al. J Chem Soc 847 1952, McIvor et al. Can J Chem 36 820 1958, Kosolapoff Organophosphorus Compounds, Wiley p 258 1950, and Cherbuliez in Organo Phosphorus Compounds (Kosolapoff & Maier eds) Wiley Vol 6 pp 211-577 1973, Beilstein 1 IV 1259.]
Waste disposal
TMP is mixed with a combustible solvent and destroyed by burning in a chemical incinerator.

Trimethyl phosphate Upstream-Materialien And Downstream Produkte

Trimethylphosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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