2-Iodopyridine

Bezeichnung:2-Iodopyridine

CAS-Nr5029-67-4

Englisch Name:2-Iodopyridine

CBNumberCB2754297

SummenformelC5H4IN

Molgewicht205

MOL-Datei5029-67-4.mol

2-Iodopyridine physikalisch-chemischer Eigenschaften

Schmelzpunkt	118-120℃
Siedepunkt	52 °C (lit.)
Dichte	1.928 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.6320(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	Solid
pka	pK1:1.82(＋1) (25°C)
Farbe	Pale yellow
Wasserlöslichkeit	Slightly soluble in water.
Sensitive	Light Sensitive
InChIKey	CCZWSTFVHJPCEM-UHFFFAOYSA-N
CAS Datenbank	5029-67-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29333990

Gefahreninformationscode (GHS)

2-Iodopyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Light yellow liquid
Verwenden
2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Verwenden
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Reaktionen
2-Iodopyridine and 3-alkoxy-2-iodopyridines are oxidized by DMDO to give PyIO2 , which serve as oxidants for alcohols and sulfides.
In palladium-catalyzed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine were coupled with CO and various primary and secondary amines. The biologically relevant N-substituted nicotinamides and 3-pyridyl-glyoxylamides were obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The chemoselectivity towards the ketoamide can be increased by the elevation of CO pressure. On the other hand, N-alkyl and N-aryl-carboxamides were obtained exclusively from CO pressure of 1 to 90 bar by using 2-iodopyridine and iodopyrazine.

Pd-catalyzed aminocarbonylation of 2-iodopyridine and 3-iodopyridine with primary and secondary amines.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6757, 1990 DOI: 10.1016/S0040-4039(00)97163-6
Allgemeine Beschreibung
2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.

2-Iodopyridine Upstream-Materialien And Downstream Produkte

2-Iodopyridine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5029-67-4, 2-Iodopyridine Verwandte Suche:

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