PROSTAGLANDIN D2

Bezeichnung:PROSTAGLANDIN D2

CAS-Nr41598-07-6

Englisch Name:PROSTAGLANDIN D2

CBNumberCB2433095

SummenformelC20H32O5

Molgewicht352.47

MOL-Datei41598-07-6.mol

PROSTAGLANDIN D2 physikalisch-chemischer Eigenschaften

Schmelzpunkt	68°C
Siedepunkt	406.07°C (rough estimate)
alpha	+7.5°(D/21℃)(c=1,THF)
Dichte	1.0601 (rough estimate)
Brechungsindex	1.6120 (estimate)
storage temp.	-20°C
Löslichkeit	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)
pka	4.76±0.10(Predicted)
Aggregatzustand	White solid
Farbe	White to Light Orange
BRN	2170623
Stabilität	Light Sensitive

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60-22
S-Sätze:	53-22-26-36
WGK Germany	3
RTECS-Nr.	UK7930000
F	10

Gefahreninformationscode (GHS)

PROSTAGLANDIN D2 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Prostaglandin D₂ (PGD₂) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ of 6.8 μM.
Verwenden
Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.
Definition
ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s ereoisomer).
Biochem/physiol Actions
Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.

PROSTAGLANDIN D2 Upstream-Materialien And Downstream Produkte

PROSTAGLANDIN D2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

41598-07-6, PROSTAGLANDIN D2 Verwandte Suche:

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