Pyrethrine und Pyrethroide

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H312：Gesundheitsschädlich bei Hautkontakt.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Pyrethrins Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  SCHWACH GELBES, BEWEGLICHES öL MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen unter Bildung von Dunst und reizenden Rauchen. Reagiert mit starken Oxidationsmitteln unter Feuer- und Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV: 5 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2008).
  MAK: IIb (nicht festgelegt, aber Informationen vorhanden) Sensibilisierung der Haut; (DFG 2008).
  EG Arbeitsplatz-Richtgrenzwerte: 1 mg/m? (als TWA) (gereinigt von sensibilisierenden Lactonen); (EG 2006)
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf das Nervensystem.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Wiederholter oder andauernder Hautkontakt kann zu Hautsensibilisierung führen. Wiederholte oder andauernde Inhalation kann asthmatische Beschwerden hervorrufen.

• LECKAGE

  Belüftung. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, A/P2-Filter für organische Dämpfe und schädlichen Staub.

• R-Sätze Betriebsanweisung:

  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S13:Von Nahrungsmitteln, Getränken und Futtermitteln fernhalten.
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Beschreibung

  Pyrethrins/Pyrethrum are natural insecticides produced by certain Chrysanthemum species of plants. In contrast, Permethrin (‘per-meth-rin’) is a synthetic, man-made insecticide, whose chemical structure is based on natural pyrethrum. Pyrethrum was first recognised as having insecticidal properties around 1800 in Asia and was used to kill ticks and various insects such as fleas and mosquitoes. Six individual chemicals have active insecticidal properties in the pyrethrum extract, and these compounds are called pyrethrins. Pyrethrum are viscous, tan-coloured brown resins, liquids, or solids which inactivate readily in air. Pyrethrum are soluble in organic solvents such as alcohol, kerosene, nitromethane, petroleum ether, carbon tetrachloride, and ethylene dichloride. A quick acting liquid insecticide especially suited for control of insect pests of vegetables, ornamentals, and exotic crops. The piperonyl butoxide ingredient is used to enhance the activity of the permethrin (synergist).
  Pyrethrum has been used effectively to control insects for decades and is nonpersistent, decomposing rapidly in the environment. This rapid degradation of pyrethrum has resulted in little known cases of insect resistance, making it an excellent choice for the control of agricultural pests, control of insects on pets and/or livestock. Pyrethrum powder is toxic to ants, roaches, silverfish, bed bugs, fleas, wasps, spiders, crickets, mosquitoes, and just about every other category of unwanted house or garden pest. Because it decomposes rapidly in the environment, pyrethrum has been approved for a wide range of indoor and outdoor uses, including homes, restaurants, broad-scale spraying operations, and organic farms.
  
  Pyrethrins break down quickly in the environment, especially when exposed to natural sunlight. Pyrethroids are manufactured chemicals that are very similar in structure to the pyrethrins, but are often more toxic to insects, as well as to mammals, and last longer in the environment than pyrethrins. Pyrethrins and pyrethroids are often combined commercially with other chemicals called synergists, which enhance the insecticidal activity of the pyrethrins and pyrethroids. The synergists prevent some enzymes from breaking down the pyrethrins and pyrethroids, thus increasing their toxicity. Technical-grade (concentrated) pyrethrins and pyrethroids are usually mixed with carriers or solvents to produce a commercial-grade formulated product.

• Chemische Eigenschaften

  Pyrethrum is a brown, viscous oil or solid. Oxidizes readily in air. Insoluble in water; soluble in other common sol- vents. Incompatible with alkalies.

• Chemische Eigenschaften

  Pyrethrum , derived from extracts of the Chrysanthemum cinerariaefolinum plant, is a combination of six pyrethrin isomers, namely, pyrethrin 1, pyrethrin 2, cinerin 1, cinerin 2, jasmolin 1, and jasmolin 2. Pyrethroids are synthetically derived commercial compounds similar to pyrethrum. Pyrethrins and pyrethriods are insoluble in water and have a low vapor pressure. Pyrethrum is subject to photodegradation and is oxidized rapidly in the presence of air (U.S. EPA, 2006c; ATSDR, 2003).

• Verwenden

  Household insecticide (flies, mosquitoes, gar- den insects, etc.).

• Verwenden

  Pyrethrum is used to control a wide range of insects and mites in public health, stored products, animal houses and on domestic and farm animals. It is used on glasshouse crops but has relatively limited use on field crops, vegetables and fruit. It is normally used with synergists such as piperonyl butoxide which inhibits metabolic detoxification.

• Verwenden

  Pyrethrins are used to kill a number of different flying and crawling insects and arthropods. First registered in the 1950s, currently over 1350 end-use products containing pyrethrins are available for agricultural, commercial, residential, and public health areas. They are used as household insecticides, as grain protectants, and to control pests on edible products just prior to harvest in a variety of locations, including residential, public, and commercial buildings, animal houses, warehouses, fields, and green houses. Pyrethrins are also extensively used in the field of veterinary medicine (U.S. EPA, 2006c; ATSDR, 2003).
  Commercially available pyrethroids include allethrin, bifenthrin, bioresmethrin, cyfluthrin, cyhalothrin, cypermethrin, deltamethrin, esfenvalerate (fenvalerate), flucythrinate, flumethrin, fluvalinate, fenpropathrin, permethrin, phenothrin, resmethrin, tefluthrin, tetramethrin, and tralomethrin.

• Indications

  Pyrethrins, rapid-acting compounds, derived from chrysanthemum plants, are the leading over-the-counter louse remedy. These compounds interfere with neural transmission, leading to paralysis and death. Piperonyl butoxide (PBO) potentiates the pyrethrins by inhibiting the hydrolytic enzymes responsible for pyrethrin metabolism in arthropods.

• Definition

  Pyrethrolone ester of chrysanthemummonocarboxylic acid. Most potent insecticidal ingredient of pyrethrum flowers.

• Air & Water Reaktionen

  Oxidize relatively rapidly in air. Water emulsifiable.

• Reaktivität anzeigen

  PYRETHRINS decompose rapidly in base; may generate heat with caustic solutions. May also react with acids to liberate heat. Generate flammable hydrogen with alkali metals and hydrides.

• Hazard

  Toxic by ingestion and inhalation.

• Health Hazard

  Pyrethrum dust causes dermatitis and occasionally sensitization.The primary effect in humans from exposure to pyrethrum is dermatitis. The usual lesion is a mild erythematous dermatitis with vesicles, papules in moist areas, and intense pruritis; a bullous dermatitis may develop.
  Some persons exhibit sensitivity similar to pollinosis, with sneezing, nasal discharge, and nasal stuffiness.2 A few cases of asthma due to pyrethrum mixtures have been reported; some of the people involved had a previous history of asthma with allergy to a wide spectrum of substances.

• Brandgefahr

  Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot.

• Pharmakologie

  The chrysanthemates (pyrethrin I, cinerin I, and jasmolin I) are generally more potent for insecticidal kill, whereas the pyrethrates (pyrethin II, cinerin II, and jasmolin II) cause more rapid knockdown. When combined with synergists, the pyrethrins are effective at low doses in causing knockdown and kill of a wide variety of pests. Pyrethrins exert their effects primarily by acting on sodium channels in nerves to disturb nerve conductance . Two distinct effects, referred to as type I and type II, have been defined for pyrethrins.

• Clinical Use

  Because of the high cost and rapid degradation of the pyrethrins, they usually are combined with piperonyI butoxide, a synergist. PiperonyI butoxide has no insecticidal activity in it own right but is thought to inhibit the cytochrome P450 enzyme of the insect, thus preventing an oxidative inactivation of the pyrethrins by the parasite. The combination is used in a 10:1 ratio of . piperonyl butoxide to pyrethrins. The mixture is used for treatment of Pedicul us humanus capitis, Pediculus humanus corporis, and Phthir'us pubis. Various dosage forms are available, including a gel, shampoo, and topical solution.

• mögliche Exposition

  Pyrethrins are used as an ingredient of various contact insecticides. Those engaged in the isolation, formulation, or application of these materials.

• Environmental Fate

  If released to air, the relatively low vapor pressure indicates that the pyrethrins and pyrethroids will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase compounds are rapidly degraded by direct photolysis and by reaction with photochemically produced hydroxyl radicals and ozone; the half-lives for these reactions in air are estimated to be 1.3 h and 17 min, respectively. Particulates may travel long distances and are removed from the atmosphere by wet or dry deposition (HSDB, 2013; ATSDR, 2003). Pyrethrins and pyrethroids are strongly adsorbed to the soil surfaces so they are not expected to be mobile. The compounds also strongly adsorb to suspended solids and sediment in the water column. Thus, partitioning to solids attenuates volatilization from soil and water surfaces. Pyrethrins and pyrethroids are often used indoors in sprays or aerosol bombs, and the volatilization rates from glass or floor surfaces may be significantly faster than from soils since these compounds are not likely to adsorb as strongly to these surfaces (ATSDR, 2003). These insecticides are readily biodegraded by microorganisms.
  Pyrethrins and pyrethroids bioconcentrate in aquatic organisms, including fish, oysters, and insects. The bioconcentration factor for several commercial products in three species of fish ranged from 180 to 1200 depending on the amount of dissolved organic matter in the water column (ATSDR, 2003).

• Stoffwechselwegen

  Each year about 200,000 kg of pyrethrins are used as a crop insecticide, much of it in enclosed conditions, and in public and animal health. Its effectiveness outdoors is limited by the high photo-instability of its components. This factor, and the great complexity of the mixture, has limited studies on its metabolic fate. The environmental fate of pyrethrum has been the subject of an excellent review by Crosby (1995). He points out that, in spite of its still quite wide use, the environmental fate of its components is largely unknown. The review deals with transport processes (partitioning, volatilisation, adsorption, etc.), photochemical and chemical degradation and environmental biotransformation (soil and water) as predicted from the limited amount of data on the pure components and that obtained for the closely related synthetic analogues, e.g. the allethrins, phenothrin and the resmethrins. This is a valuable paper by one of the foremost scientists in the field. The fates of the chrysanthemic acid moiety and of the synthetic alcohol moieties of similar structure to those in the natural pyrethrins (e.g. allethrolone) are considered to be useful models for the fate of pyrethrin. The pyrethrin I series (chrysanthemate esters) appears to have higher partition coefficients, bioconcentration factors, volatility and soil adsorption, but lower aqueous solubility than does the pyrethrin II series (pyrethrate esters). This suggests that pyrethrin I (PI), cinerin I (CI) and jasmolin I (JI) may be more readily transported in the environment.
  Photodegradation and biotransformation should be very rapid for both series. The limited experimental evidence given below supports these predictions.
  The best mformation is available for animals and most of the infomation given below is derived from in vitro studies using rodent liver microsomes. The constituents of pyrethrum appear to differ from the synthetic pyrethroids in being relatively resistant to metabolic hydrolysis. Metabolism is mainly via hydroxylation and elimination after conjugation.

• Versand/Shipping

  UN2902 Pesticides, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• Degradation

  Pyrethrum is stable for years in the dark at ambient temperature. In light, rapid photo-oxidation occurs with a DT₅₀ in sunlight of ﹤15 minutes. Hydrolysis to the component acids and alcohols occurs under basic conditions.
  Exposure to sunlight (Ruzo, 1982) affords a complex mixture of products which is insecticidally inactive. Reactions include isomerisation, hydrolysis and oxidation. Products derived from the photomodification of the chrysanthemic acid moiety of pyrethrin I (PI) (Chen and Casida, 1969) include the analogues of those described under phenothrin. Simultaneous reactions at the alcohol moieties lead to very complex mixtures of products.

• Toxicity evaluation

  The pyrethrins have low toxicity to mammals, and death after exposure to pyrethrins is rare. Their lability in light and air leads to a lack of residual activity and the need for repeated applications. This has restricted the use of the natural pyrethrins in the animal health sector.

• Inkompatibilitäten

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Compounds of the car- boxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic com- pounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sul- fate and oxides of sulfur).

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