9-CIS-RETINOIC ACID Struktur

9-CIS-RETINOIC ACID

Bezeichnung:9-CIS-RETINOIC ACID

CAS-Nr5300-03-8

Englisch Name:9-CIS-RETINOIC ACID

CBNumberCB2386395

SummenformelC20H28O2

Molgewicht300.44

MOL-Datei5300-03-8.mol

9-CIS-RETINOIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	189-191°C
Siedepunkt	462.8±14.0 °C(Predicted)
Dichte	1.011±0.06 g/cm3(Predicted)
RTECS-Nr.	VH6450000
storage temp.	-20°C
Löslichkeit	Acetonitrile (Very Slightly), Chloroform (Slightly), DMSO (Slightly), Ethanol (
pka	4.73±0.33(Predicted)
Aggregatzustand	Light yellow to orange crystalline powder.
Farbe	Pale Yellow to Yellow
Biologische Quelle	natural
Wasserlöslichkeit	Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
Sensitive	Moisture & Light Sensitive
Stabilität	Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
CAS Datenbank	5300-03-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	61-36/37/38
S-Sätze:	53-26-36/37/39-45
WGK Germany	3
HS Code	29162090
Giftige Stoffe Daten	5300-03-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

9-CIS-RETINOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Alitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.
Chemische Eigenschaften
Pale Yellow Solid
Originator
Ligand (US)
Verwenden
9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.
Verwenden
An endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.
Indications
Alitretinoin (Panretin) is a naturally occurring endogenous retinoid that binds to and activates all known retinoid receptors (both RARs and RXRs). It is approved for the topical treatment of cutaneous lesions of Kaposi’s sarcoma. Most patients have local irritation while using alitretinoin gel; however, the irritation rarely necessitates discontinuation of therapy.
Definition
ChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Trademarks
Panretin (Ligand).
Biochem/physiol Actions
Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.

9-CIS-RETINOIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5300-03-8, 9-CIS-RETINOIC ACID Verwandte Suche:

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