Triptorelin

Bezeichnung:Triptorelin

CAS-Nr57773-63-4

Englisch Name:Triptorelin

CBNumberCB2366465

SummenformelC64H82N18O13

Molgewicht1311.45

MOL-Datei57773-63-4.mol

Triptorelin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>180°C (dec.)
alpha	D23 -58.8° (c = 0.33 in acetic acid)
Dichte	1.52±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)
Aggregatzustand	powder
pka	9.82±0.15(Predicted)
Farbe	White to Off-White
Stabilität	Hygroscopic
InChIKey	HPPONSCISKROOD-OYLNGHKZSA-N
CAS Datenbank	57773-63-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60
S-Sätze:	53-22-36/37/39-45
WGK Germany	3
HS Code	2937190000

Gefahreninformationscode (GHS)

Triptorelin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Decapeptyl is a modified (D-Trp⁶) LH-RH. Like recently marketed buserelin and leuprolide (I), it is useful in achieving medical castration in the treatment of advanced prostate cancer.
Originator
Tulane Univ. (USA)
Verwenden
Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation.
Verwenden
promoting ovulation
Verwenden
[D-Trp6]-LH-RH (luteinizing hormone releasing hormone) has been used to study whether the (M^. – X) region in electron capture dissociation provides information on amino acid composition of polypeptides. It is also used to study the effect of LH-RH on the production of progesterone (P), estradiol (E2) or human chorionic gonadotropin (hCG) by JEG-3 choriocarcinoma cells.
Definition
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Trademarks
Trelstar (Watson).
Biochem/physiol Actions
Potent LH-RH agonist with enhanced biological activity due to its slower rate of degradation. Like [D-Lys6]-LH-RH, the D-Trp6 analog has been shown to be effective against cancers expressing the LH-RH receptor. However, unlike the D-Lys6 analog, it is generally used in the unconjugated form.
Clinical Use
Triptorelin pamoate is another superagonist of GnRH, which like nafarelin acetate contains only a single amino acid substitution (D-Trp6 for Gly6) when compared to the natural hormone. In the treatment of advanced prostate cancer, it is important to reduce serum testosterone levels to very low levels, which can be achieved surgically by orchiectomy. When this surgical method is unacceptable to the patient, an alternative approach is “chemical castration,” which can be achieved by use of estrogen therapy, leuprolide,goserelin or histrelin acetates, and now, triptorelin pamoate. This product is available for IM depot injection (monthly or every 3 months), wherein serum testosterone concentration drops to a level generally seen in surgically castrated men.
Nebenwirkungen
The side effects of Triptorelin: Painful or difficult urination, burning when you urinate, blood in the urine; bone pain; (in children) new or worsening signs of puberty; a seizure; chest pain or pressure, pain spreading to your jaw or shoulder; sudden numbness or weakness, slurred speech; increased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; loss of movement in any part of your body; high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or nerve problems - back pain, muscle weakness, problems with balance or coordination, severe numbness or tingling in your legs or feet, loss of bladder or bowel control.
Stoffwechsel
The metabolism of triptorelin in humans is unknown, but it is thought to be hydrolysed in the plasma and excreted in the urine as inactive metabolites.
Mode of action
Triptorelin is a gonadotrophin releasing hormone (GnRH) blocker. This means it stops messages from a part of the brain called the hypothalamus that tells the pituitary gland Open a glossary item to produce luteinising hormone. Luteinising hormone tells the testicles to produce testosterone Open a glossary item. So, blocking GnRH stops the testicles producing testosterone. Prostate cancer depends on testosterone to grow. So triptorelin can shrink the cancer or slow its growth. In women, it stops the ovaries Open a glossary item from producing oestrogen. Some breast cancers depend on oestrogen to grow. Lowering the level of oestrogen can slow or stop the growth of the cancer.

Triptorelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57773-63-4, Triptorelin Verwandte Suche:

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