Pyridaphention

Bezeichnung:Pyridaphention

CAS-Nr119-12-0

Englisch Name:Pyridaphenthion

CBNumberCB2292780

SummenformelC14H17N2O4PS

Molgewicht340.33

MOL-Datei119-12-0.mol

Synonyma

O,O-Diethyl-O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl)thiophosphat

Pyridaphention

Pyridaphention physikalisch-chemischer Eigenschaften

Schmelzpunkt	54.5～56.5℃
Siedepunkt	416.2±28.0 °C(Predicted)
Dichte	1.30±0.1 g/cm3(Predicted)
Dampfdruck	1.47×10^-6 Pa (20 °C)
Flammpunkt	-4 °C
storage temp.	APPROX 4°C
Wasserlöslichkeit	100mg l^-1 （20°C）
pka	-2.09±0.40(Predicted)
BRN	302741
Henry's Law Constant	5.1×10⁴ mol/(m³Pa) at 25℃, Ebert et al. (2023)
Major Application	agriculture
InChI	InChI=1S/C14H17N2O4PS/c1-3-18-21(22,19-4-2)20-13-10-11-14(17)16(15-13)12-8-6-5-7-9-12/h5-11H,3-4H2,1-2H3
InChIKey	CXJSOEPQXUCJSA-UHFFFAOYSA-N
SMILES	P(=S)(OCC)(OCC)OC1=NN(C2=CC=CC=C2)C(=O)C=C1
CAS Datenbank	119-12-0(CAS DataBase Reference)
NIST chemische Informationen	Phosphorothioic acid, o-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) o,o-diethyl ester(119-12-0)
EPA chemische Informationen	Pyridaphenthion (119-12-0)

Sicherheit

Kennzeichnung gefährlicher	F,Xi,N,Xn
R-Sätze:	11-36-66-67-57-51/53-20/22
S-Sätze:	26-61-33-16
RIDADR	2783
WGK Germany	3
RTECS-Nr.	TF2275000
HazardClass	6.1(a)
PackingGroup	II
Speicherklasse	3 - Flammable liquids
Hazard Classifications	Eye Irrit. 2 Flam. Liq. 2 STOT SE 3

Gefahreninformationscode (GHS)

Pyridaphenthion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36:Reizt die Augen.
R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Pyridaphenthion is a pale yellow solid, mp 54.5–56 C, vp 0.00147 mPa (20 C). Solubility in water is 100 mg/L (20 C). It is very soluble in acetone, methanol, and diethyl ether. Log Kow = 3.2.
Verwenden
Pyridaphenthion is used to control a wide range of chewing and sucking insects and mites in rice, vegetables, fruit and ornamentals.
Definition
ChEBI: Pyridaphenthion is an organic thiophosphate, an organothiophosphate insecticide and a pyridazinone. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is functionally related to a 6-hydroxy-2-phenylpyridazin-3-one.
Sicherheitsprofil
Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. When heated to decomposition it emits very toxic fumes of SOx, POx, and NOx. Used to control chewing and suckmg insects on rice, fruits, vegetables, and cereals.
Stoffwechselwegen
Pyridaphentluon is photolytically transformed into the oxon and phenylmaleic hydrazide. In the mouse its metabolism involves oxidative dearylation, oxidative desulfuration to the oxon, de-ethylation and conjugation of phenylmaleic hydrazide produced as the ultimate product of stage I metabolism and is typical of many phosphorothioates. A marked difference between metabolism in mice and rats was shown, with rats excreting no desethylpyridaphenthion and excreting all of the phenyl-maleic hydrazide in an unconjugated form.
Stoffwechsel
More than 70% of the dose administered to rats and mice was excreted within 24 h in the urine. The major metabolites excreted are phenylmaleic hydrazide and desethyl pyridafenthion-oxon. The half-life in soil is 11–24 d.
Toxicity evaluation
The acute oral LD₅₀ for rats is 769–850 mg/kg. Inhalation LC50 (4 h) for rats is >1.13 mg/L air.
Degradation
The photolysis of pyridaphenthion on a glass slide irradiated with both short wavelength UV light and light of wavelength >300 nm was investigated by Tsao et al. (1989). Samples were irradiated for 48 hours at unrecorded light intensity as thin films spread on petri dishes or in solution in water, methanol or hexane under an oxygen atmosphere. The effects of photosensitisers was also assessed in the thin film experiments. The photoproducts were analysed by TLC, GC-MS and ¹H NMR spectroscopy. Under thin film conditions pyridaphenthion was photodegraded more quickly with light >300 nm than by 254 um light and was degraded faster as a thin film than in solution. The main photoproducts from the glass surface and aqueous solution were pyridaphenthion oxon (2) and phenylmaleic hydrazide (3) (Scheme 1); the only other products were small amounts of polymers. Photosensitisers accelerated photolysis markedly with the most effective being a plant-derived natural product, cis-dehydromatricaria ester. It is notable that a simple chemical oxidation using 3-chloroperoxybenzoic acid gave the same two products, 2 and 3.

Pyridaphenthion Upstream-Materialien And Downstream Produkte

Pyridaphention Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

119-12-0, Pyridaphenthion Verwandte Suche:

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