7-(α-D-Glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-on

Bezeichnung:7-(α-D-Glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-on

Englisch Name:4-METHYLUMBELLIFERYL-ALPHA-D-GLUCOPYRANOSIDE HYDRATE

CBNumberCB2254919

SummenformelC16H18O8

Molgewicht338.31

Synonyma

7-(α-D-Glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-on

7-(α-D-Glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	171-173 °C
Siedepunkt	626.9±55.0 °C(Predicted)
Dichte	1.522±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: 50 mg/mL, clear, colorless to faintly yellow
Aggregatzustand	White solid
pka	12.73±0.70(Predicted)
Farbe	White to Off-White
BRN	1690776
InChIKey	YUDPTGPSBJVHCN-JZYAIQKZSA-N
CAS Datenbank	17833-43-1(CAS DataBase Reference)

Sicherheit

Gefahreninformationscode (GHS)

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase. 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.
Chemische Eigenschaften
white to off-white crystalline powder
Verwenden
4-Methylumbelliferyl α-D-glucopyranoside is used as a flurogenic substrate for the identification, characterization and kinetic analysis of α-D-glucosidase(s).
Verwenden
4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate in the assay of a-glucosidase,it has been used in the study of Pompe disease.
Definition
ChEBI: 4-Methylumbelliferyl-alpha-D-glucopyranoside is a member of coumarins and a glycoside.
läuterung methode
Recrystallise 4-methylumbellifer-7-yl--D-glucopyranoside from hot H2O or EtOH. [Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 IV 443.]