TYRPHOSTIN A9

Bezeichnung:TYRPHOSTIN A9

CAS-Nr10537-47-0

Englisch Name:TYRPHOSTIN A9

CBNumberCB2245711

SummenformelC18H22N2O

Molgewicht282.38

MOL-Datei10537-47-0.mol

TYRPHOSTIN A9 physikalisch-chemischer Eigenschaften

Schmelzpunkt	141-143℃ (ethanol )
Siedepunkt	424.99°C (rough estimate)
Dichte	1.0741 (rough estimate)
Brechungsindex	1.5700 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	ethanol: 20 mg/mL
Aggregatzustand	solid
pka	7.55±0.40(Predicted)
Farbe	yellow
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS Datenbank	10537-47-0(CAS DataBase Reference)
EPA chemische Informationen	Malonoben (10537-47-0)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	OO3737000
HS Code	2926.90.5050
HazardClass	6.1

Gefahreninformationscode (GHS)

TYRPHOSTIN A9 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4
Verwenden
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
Verwenden
Selective inhibitor of PDGF receptor tyrosine kinase
Verwenden
SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.
Definition
ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.
Allgemeine Beschreibung
A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
Biologische Aktivität
Potent uncoupler of oxidative phosphorylation.
Biochem/physiol Actions
Cell permeable: yes
Einzelnachweise
1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721 2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225 3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794 4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33

TYRPHOSTIN A9 Upstream-Materialien And Downstream Produkte

TYRPHOSTIN A9 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

10537-47-0, TYRPHOSTIN A9 Verwandte Suche:

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