4-Chloro-3-methoxybenzoic acid

Bezeichnung:4-Chloro-3-methoxybenzoic acid

CAS-Nr85740-98-3

Englisch Name:4-Chloro-3-methoxybenzoic acid

CBNumberCB2240372

SummenformelC8H7ClO3

Molgewicht186.59

MOL-Datei85740-98-3.mol

4-Chloro-3-methoxybenzoic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	217.0 to 221.0 °C
Siedepunkt	325.4±22.0 °C(Predicted)
Dichte	1.352±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	3.85±0.10(Predicted)
Aggregatzustand	powder to crystal
Farbe	White to Almost white
CAS Datenbank	85740-98-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T,N
R-Sätze:	36/37/38-50-25
S-Sätze:	26-36/37/39-61-45
RIDADR	3077
WGK Germany	3
HazardClass	9
PackingGroup	Ⅲ
HS Code	2918999090

Gefahreninformationscode (GHS)

4-Chloro-3-methoxybenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
4-Chloro-3-methoxybenzoic acid can be used to synthesize specific drug molecules, such as a key intermediate for the antiarrhythmic drug amiodarone.
Synthese

73909-16-7

85740-98-3

B. Synthesis of 4-chloro-3-methoxybenzoic acid (0200) To crude 1-chloro-2-methoxy-4-methylbenzene (7.8 g, 50 mmol) was added an aqueous solution of potassium permanganate (KMnO4, 19.8 g, 125 mmol) (300 mL). The reaction mixture was stirred vigorously under reflux conditions for 17 h. After completion of the reaction, the filter was passed through diatomaceous earth and the filter cake was washed with hot water (200 mL). The clarified filtrate was washed with ether (2 x 150 mL) and then acidified with concentrated hydrochloric acid (HCl) to pH < 2. After addition of concentrated hydrochloric acid (9 mL), the precipitate was collected by filtration to give pure white solid 4-chloro-3-methoxybenzoic acid (5.36 g, 58% yield). Electrospray mass spectrometry (ES-MS) showed (M + H)+ peak located at m/z = 187.
Einzelnachweise
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4408 - 4414
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 5754 - 5762
[3] Archiv der Pharmazie, 2011, vol. 344, # 11, p. 745 - 754
[4] Chemical Biology and Drug Design, 2013, vol. 82, # 3, p. 336 - 347
[5] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 315 - 322

4-Chloro-3-methoxybenzoic acid Upstream-Materialien And Downstream Produkte

4-Chloro-3-methoxybenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

85740-98-3, 4-Chloro-3-methoxybenzoic acid Verwandte Suche:

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