PANCREATIC POLYPEPTIDE (BOVINE)

PANCREATIC POLYPEPTIDE (BOVINE) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  Pancreatic Polypeptide, bovine is a linear polypeptide of 36 amino acids produced in the pancreas that inhibits pancreatic secretion induced by secretin and cholecystokinin. It is a neuropeptide (NPY) receptor agonist with high affinity for NPYR4.

• in vitro

  Pancreatic Polypeptide, bovine is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca ²⁺ ) _i levels in BRIN BD11 cells at 1 μM. Pancreatic Polypeptide, bovine inhibits secretin- and cholecystokinin-stimulated pancreatic secretion. ¹²⁵ I-Pancreatic Polypeptide, bovine shows no specific binding to pancreatic acini.

• in vivo

  Pancreatic Polypeptide (25 nmol/kg bw, ip) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice. Pancreatic Polypeptide, bovine (BPP; 40 μg/kg) inhibits CCK -33-induced pancreatic protein output during the entire bovine Pancreatic Polypeptide infusion period, but shows no effect on biliary protein output during CCK-33 or CCK-8 infusion.

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