sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

Bezeichnung:sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

CAS-Nr119515-38-7

Englisch Name:sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

CBNumberCB2136802

SummenformelC12H23NO3

Molgewicht229.32

MOL-Datei119515-38-7.mol

sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate physikalisch-chemischer Eigenschaften

Schmelzpunkt	<-170°
Siedepunkt	2800C
Dichte	d20 1.07
Brechungsindex	nD20 1.4717
Flammpunkt	142°C
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Oil
pka	15.15±0.10(Predicted)
Farbe	Colourless
Henry's Law Constant	3.3×10⁵ mol/(m³Pa) at 25℃, HSDB (2015)
Kosmetik-Inhaltsstoffe Funktionen	ANTIMICROBIAL
InChI	InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3
InChIKey	QLHULAHOXSSASE-UHFFFAOYSA-N
SMILES	N1(C(OC(C)CC)=O)CCCCC1CCO
CAS Datenbank	119515-38-7
EPA chemische Informationen	Icaridin (119515-38-7)

Sicherheit

Giftige Stoffe Daten	119515-38-7(Hazardous Substances Data)
Toxizität	LD50 in rats (mg/kg): 4743 orally; >2000 dermally (Yap); LC50 in rainbow trout (96 hr): 173 mg/l; in bobwhite quail (5 day diet): >5000 ppm a.i. in diet (WHO).

Gefahreninformationscode (GHS)

sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Picaridin is an insect repellent. It inhibits A. aegypti odorant receptor 2 (AaOR2) or AaOR8 in the presence of their odorant activators, indole and octenol, respectively, expressed in Xenopus oocytes (IC₅₀s = 1,452 and 1,911 μM, respectively). Picaridin reduces the number of entries into a food chamber by female D. melanogaster in an olfactory-based choice assay. It acts synergistically with the non-pyrethroid insecticide pyrimiphos methyl to increase mortality of A. gambiae and reduce blood feeding when used at a concentration of 10 g/m² on nets surrounding guinea pig cages. Formulations containing picaridin have been used as insect repellents against flies, mosquitoes, chiggers, ticks, and fleas.
Chemische Eigenschaften
Colorless Liquid
Verwenden
Insect repellent.
Verwenden
Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources.Insect repellent.
Definition
ChEBI: Butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate is a carboxylic acid and a member of piperidines.
Vorbereitung Methode
Commercial production of icaridin involves a highly optimised chemical synthesis process developed to meet global demand for safe and effective insect repellents. The active ingredient is a piperidine derivative, and its synthesis typically starts with cyclohexane derivatives, which undergo a series of reactions including chlorination, etherification, and nitrile formation to build the final molecular structure.
Hazard
A reproductive hazard.
Mechanism of action
Topically applied, repellent. Odorant receptor. It has been proposed that icaridin may bind to odorant binding protein 1 (AgamOBP1).
Einzelnachweise
[1] JONATHAN D BOHBOT Joseph C D. Insect repellents: modulators of mosquito odorant receptor activity.[J]. PLoS ONE, 2010: e12138. DOI: 10.1371/journal.pone.0012138
[2] ZAINULABEUDDIN SYED. Generic insect repellent detector from the fruit fly Drosophila melanogaster.[J]. PLoS ONE, 2011: e17705. DOI: 10.1371/journal.pone.0017705
[3] CéDRIC PENNETIER. Synergy between repellents and non-pyrethroid insecticides strongly extends the efficacy of treated nets against Anopheles gambiae.[J]. ACS Applied Bio Materials, 2007: 38. DOI: 10.1186/1475-2875-6-38
Pestizidtyp
Insecticide; Repellent; Veterinary substance

sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

119515-38-7, sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate Verwandte Suche:

Send Inquriy