Enoxaparin sodium Struktur

Enoxaparin sodium

Bezeichnung:Enoxaparin sodium

CAS-Nr679809-58-6

Englisch Name:Enoxaparin sodium

CBNumberCB1994513

SummenformelC57H82N4Na4O53S3

Molgewicht0

MOL-DateiMol file

Enoxaparin sodium physikalisch-chemischer Eigenschaften

Schmelzpunkt	>191°C (dec.)
storage temp.	Room Temperature, Under inert atmosphere
Löslichkeit	Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White

Sicherheit

HS Code	3001900190
Giftige Stoffe Daten	679809-58-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Enoxaparin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Enoxaparin sodium is the sodium salt of a low-molecular-mass heparin that is obtained by alkaline depolymerisation of the benzyl ester derivative of heparin from porcine intestinal mucosa. Enoxaparin sodium is an antithrombotic agent (ATC code B01AB05) characterized by a higher ratio of antithrombotic activity to anticoagulant activity compared to unfractionated heparin.
Specifically, Enoxaparin sodium as the sodium salt of depolymerized Heparin is subject to characteristic structural modifications from the effects of the depolymerization reaction. Characteristic structures such as partial transformation of glucosamines into mannosamines, formation of 1,6-anydro derivatives and 2,3 epoxide residues with subsequent conversion to galacturonic acid and the change in the proportion of the sulfated and non-sulfated residues are some of the changes that constitute Enoxaparin a structurally difficult to characterize molecule. As such no single technique or parameter is adequate to fully characterize the Enoxaparin molecule as part of a biosimilarity exercise against the reference.
Chemische Eigenschaften
degree of sulphatation is ~ 2 per disaccharide
Verwenden
Enoxaparin is marketed under the brand name Lovenox and as a generic drug under the name enoxaparin sodium for injection.
Enoxaparin sodium is intended for use in the treatment of deep vein thrombosis; prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, and treatment of acute deep vein thrombosis.
Verwenden
Enoxaparin Sodium can be used as a biomarker for diagnosis of atrial fibrillation cause of stroke.
Indications
Enoxaparin sodium is a gold standard for antithrombosis which has the largest number of indications among all LMWHs. Prophylaxis of vein thrombosis diseases (prevent intra-vein thrombosis), treatment of deep venous thrombosis, Prevention of thrombus formation in the in vitro circulation during hemodialysis, treatment of acute unstable angina and non-Q-wave myocardial infarction, administered with Aspirin.
Trademarks
Lovenox (Sanofi Aventis).
Veterinary Drugs and Treatments
Enoxaparin may be useful for prophylaxis or treatment of deep vein thrombosis or pulmonary embolus. Recent pharmacokinetic work in dogs and cats, raises questions whether the drug can be effectively and practically administered long-term. In humans, it is also indicated for prevention of ischemic complications associated with unstable angina/non Q-wave MI.

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