Dichlorison

dichlorisone Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Diloderm ,Schering,US,1960

• Verwenden

  Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.

• Manufacturing Process

  A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
  with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

• Therapeutic Function

  Antipruritic, Antihistaminic, Appetite stimulant

dichlorisone Upstream-Materialien And Downstream Produkte

Dichlorison Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(7)Suppliers

7008-26-6, dichlorisone Verwandte Suche: