Tolycain

tolycaine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Tolycaine Hydrochloride,ZYF Pharm Chemical

• Definition

  ChEBI: Tolycaine is an amidobenzoic acid.

• Manufacturing Process

  A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of benzene was added 125 ml of saturated solution of sodium acetate and then at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1 hour at room temperature. The mixture was filtered. The organic layer was with 10% solution of potassium carbonate and dries under calcium chloride. By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from a mixture acetic acid and ligroin); yield 21.8 g.
  A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After cooling the diethyl amine hydrochloride was deleted by filtration. The organic layer was washed with 2 N hydrochloric acid. To the solution was added potassium carbonate. The product was extracted with ether and distilled.

• Trademarks

  Tolycaine Hydrochloride is JAN.

• Therapeutic Function

  Local anesthetic

tolycaine Upstream-Materialien And Downstream Produkte

Tolycain Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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