(2-Phenylethyl)hydrazin-sulfat(1:1)

Bezeichnung:(2-Phenylethyl)hydrazin-sulfat(1:1)

CAS-Nr156-51-4

Englisch Name:Phenelzine Sulfate

CBNumberCB1719066

SummenformelC8H14N2O4S

Molgewicht234.27

MOL-Datei156-51-4.mol

Synonyma

Phenelzinhydrogensulfat

(2-Phenylethyl)hydrazin-sulfat(1:1)

(2-Phenylethyl)hydrazin-sulfat(1:1) physikalisch-chemischer Eigenschaften

Schmelzpunkt	166.5-167.5 °C
storage temp.	2-8°C
Löslichkeit	Freely soluble in water; practically insoluble in ethanol (96%) and in ether .
Aggregatzustand	A solid
Merck	13,7300
CAS Datenbank	156-51-4
IARC	3 (Vol. 24, Sup 7) 1987

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	MV8750000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2928002500
Toxizität	LD50 orally in mice: 156 mg/kg (Gylys)

Gefahreninformationscode (GHS)

Phenelzine Sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Chemische Eigenschaften
A white powder or pearly platelets.
Originator
Nardil ,Parke Davis, US ,1959
Verwenden
antihistaminic
Verwenden
Phenelzine Sulfate is a hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidep ressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.
Definition
ChEBI: Phenelzine sulfate is an organic molecular entity.
Manufacturing Process
To a refluxing solution containing 147.5 grams of 85% hydrazine hydrate in 500 cc of ethanol was added, during a period of 5 hours, 92.5 grams of phenethylbromide (0.50 mol) in 150 cc of ethanol. Stirring and refluxing were continued for two hours. The ethanol was removed by distillation and the residue extracted repeatedly with ether. The ether was dried with potassium carbonate and the product base collected by distillation, BP 74°C/0.1 mm, yield 52.3 grams (77%). The base is reacted with sulfuric acid in propanol to give the sulfate.
Trademarks
Nardil (Parke-Davis).
Therapeutic Function
Psychostimulant
Allgemeine Beschreibung
Phenelzine sulfate, 2-(phenylethyl)hydrazine sulfate(Nardil), is an effective antidepressant agent. A mechanismbasedinactivator, it irreversibly inactivates the enzyme orits cofactor, presumably after oxidation to the diazine,which can then break up into molecular nitrogen, a hydrogen atom, and a phenethyl free radical. The latter would bethe active species in irreversible inhibition.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Phenelzine Sulfate Upstream-Materialien And Downstream Produkte

(2-Phenylethyl)hydrazin-sulfat(1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

156-51-4, Phenelzine Sulfate Verwandte Suche:

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