Bilobalide

Bezeichnung:Bilobalide

CAS-Nr33570-04-6

Englisch Name:Bilobalide

CBNumberCB1688713

SummenformelC15H18O8

Molgewicht326.3

MOL-Datei33570-04-6.mol

Bilobalide physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°
alpha	57820 -64.3° (c = 2 in acetone)
Siedepunkt	651.7±55.0 °C(Predicted)
Dichte	1.56±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	Acetone (Slightly), Methanol (Slightly)
pka	11.74±0.40(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Merck	14,1220
Stabilität	Hygroscopic
LogP	-0.450 (est)
CAS Datenbank	33570-04-6(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	LV1665000
F	10
HS Code	29322090

Gefahreninformationscode (GHS)

Bilobalide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
Verwenden
Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.
Verwenden
Reference Standard in the analysis of herbal medicinal products
Definition
ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
Allgemeine Beschreibung
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Enzyminhibitor
This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.

Bilobalide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

33570-04-6, Bilobalide Verwandte Suche:

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