CLORGYLINE HYDROCHLORIDE Struktur

N-(3-(2,4-Dichlorphenoxy)propyl)-N-methyl-2-propin-1-amin-hydrochlorid

Bezeichnung:N-(3-(2,4-Dichlorphenoxy)propyl)-N-methyl-2-propin-1-amin-hydrochlorid

CAS-Nr17780-75-5

Englisch Name:CLORGYLINE HYDROCHLORIDE

CBNumberCB1445257

SummenformelC13H16Cl3NO

Molgewicht308.63

MOL-Datei17780-75-5.mol

Synonyma

N-[3-(2,4-Dichlorphenoxy)propyl]-N-methyl-2-propinylaminhydrochlorid

N-(3-(2,4-Dichlorphenoxy)propyl)-N-methyl-2-propin-1-amin-hydrochlorid

N-(3-(2,4-Dichlorphenoxy)propyl)-N-methyl-2-propin-1-amin-hydrochlorid physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
Aggregatzustand	A crystalline solid
Farbe	White to off-white

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	UI0675000
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

CLORGYLINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (K_is = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ₁ on Jurkat human T lymphocyte cells (IC₅₀ = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.
Verwenden
Antidepressant;Monoamine oxidase A inhibitor
Verwenden
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:
- in MAO-A biochemical assay
- to study its effects on the transit of serotonin (5-HT) in the human placenta explants
- to study its effects on human prostate cancer cells
Biochem/physiol Actions
MAO-A inhibitor.
Einzelnachweise
[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.

N-(3-(2,4-Dichlorphenoxy)propyl)-N-methyl-2-propin-1-amin-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

17780-75-5, CLORGYLINE HYDROCHLORIDE Verwandte Suche:

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