HOE 140

Bezeichnung:HOE 140

CAS-Nr130308-48-4

Englisch Name:HOE 140

CBNumberCB1318492

SummenformelC59H89N19O13S

Molgewicht1304.52

MOL-Datei130308-48-4.mol

HOE 140 physikalisch-chemischer Eigenschaften

Dichte	1.60±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)
Aggregatzustand	powder
pka	3.60±0.21(Predicted)
Farbe	white
Wasserlöslichkeit	Soluble to 1 mg/ml in water
Sequenz	H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
InChIKey	QASONHYHOCRAHL-DOMVFXHKSA-N
CAS Datenbank	130308-48-4

Sicherheit

WGK Germany

HOE 140 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].
Verwenden
Antagonist (bradykinin).
Definition
ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.
Trademarks
Metastat (CollaGenex).
Biologische Aktivität
Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20 nmol kg^?1, inhibition still amounted to 60%, whereas the effect of 200 nmol kg^?1 of d-Arg—[Hyp2, Thi5,8, d-Phe7]BK was not significant. In receptor binding studies in guinea-pig ileum preparations, Hoe 140 showed an IC50 of 1.07 × 10?9mol l^?1 and a KI value of 7.98 × 10?10 mol l^?1.
Lager
Store at -20°C
Einzelnachweise
[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.

HOE 140 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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