2-Naphthaleneboronic acid

Bezeichnung:2-Naphthaleneboronic acid

CAS-Nr32316-92-0

Englisch Name:2-Naphthaleneboronic acid

CBNumberCB1282654

SummenformelC10H9BO2

Molgewicht171.99

MOL-Datei32316-92-0.mol

2-Naphthaleneboronic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	269-275 °C(lit.)
Siedepunkt	381.9±25.0 °C(Predicted)
Dichte	1.21±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Wasserlöslichkeit	Slightly soluble in water
pka	8.53±0.30(Predicted)
Aggregatzustand	Crystalline Powder and/or Chunks
Farbe	White to off-white
BRN	2936449
InChIKey	KPTRDYONBVUWPD-UHFFFAOYSA-N
CAS Datenbank	32316-92-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
TSCA	No
HazardClass	IRRITANT
HS Code	29319090

Gefahreninformationscode (GHS)

2-Naphthaleneboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
yellow crystal powde
Verwenden
suzuki reaction
Verwenden
Used in a study of an enantioselective rhodium-catalyzed addition of aryl boronic acids to 2,2,2-trifluoroacetophenones leading to chiral, tertiary trifluoromethyl alcohols. Also employed in a study of a palladium-catalyzed addition of aryl boronic acids to nitriles providing aryl ketones and to aryloxy nitriles providing benzofurans.
Synthese
To a two-neck 250mL round bottom flask, triisopropyl borate (3.30mL, 29.06mmol) and 3-bromoquinoline (3.00g, 14.49mmol) was dissolved in dry THF (100mL), then n-butyllithium (14.50mL of a 2M solution in hexane, 29.00mmol) was added dropwise via a dropping funnel over 1h under N2 at-78°C. After 2h, the acetone/dry ice bath was removed, and the reaction solution was allowed to warm to 0°C. The reaction was then quenched with a 2M HCl solution, and the pH value was adjusted to 7 with a solution of 2M NaHCO3. The resulting solution was extracted with ethyl acetate (EA) (3×100mL). The combined organic layers were dried with MgSO4 and evaporated to dryness. n-Hexane was then added to precipitated the product 2-Naphthaleneboronic acid as a white solid (80% yield).

2-Naphthaleneboronic acid Upstream-Materialien And Downstream Produkte

2-Naphthaleneboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

32316-92-0, 2-Naphthaleneboronic acid Verwandte Suche:

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