METHYLENEBIS(PHOSPHONIC DICHLORIDE)

Bezeichnung:METHYLENEBIS(PHOSPHONIC DICHLORIDE)

CAS-Nr1499-29-2

Englisch Name:METHYLENEBIS(PHOSPHONIC DICHLORIDE)

CBNumberCB1147951

SummenformelCH2Cl4O2P2

Molgewicht249.78

MOL-Datei1499-29-2.mol

METHYLENEBIS(PHOSPHONIC DICHLORIDE) physikalisch-chemischer Eigenschaften

Schmelzpunkt	102-104 °C(lit.)
Siedepunkt	329.0±25.0 °C(Predicted)
Dichte	1.798±0.06 g/cm3(Predicted)
Löslichkeit	Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly)
Aggregatzustand	crystalline powder
Farbe	Faint beige
Stabilität	Moisture Sensitive

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	14-34
S-Sätze:	26-27-36/37/39-45
RIDADR	UN 3261 8/PG 1
WGK Germany	3
HS Code	2931599090

Gefahreninformationscode (GHS)

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R14:Reagiert heftig mit Wasser.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Methylenebis (phosphonic dichloride) is an organophosphorus compound commonly used in phosphonation reactions. It is more reactive and faster than POCl. This is due to the fact that the phosphorus centre is more electrophilic due to the lack of electron feedback from the CH2 group.
Chemische Eigenschaften
Crystals of the Methylenebis(phosphonic dichloride) are monoclinic, space group C2/c, with a= 15·866(5), b= 5·845(1), c= 9·161 (3)A, β= 106·59(2)°, Z= 4. The molecules, which display a crystallographically imposed C2 symmetry, are linked together through two C–H ? O(P) hydrogen bonds, of length 3·23(1)A, into infinite chains in the z direction. Rigid-body analysis reveals that pronounced rotational and translational motions are associated with the axis of minimum inertia and least cross-section. Bond lengths (corrected for libration) are: P–Cl 1·994(2) and 1·997 (2), PO 1·463(4), P–C 1·804(4)A; angle P–C–P 116·4(4)°, the structure was solved by direct methods and refined by full-matrix least-squares to R 0·041 for 641 diffractometer-measured unique reflections^[1].
Verwenden
Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.
Application
Methylenebis (phosphonic dichloride) can be used for the following studies:
(1) Synthesis of mycophenolic methylenebis(phosphonate) derivatives.
(2) Phosphonylation of nucleosides.
(3) Preparation of P,P′-partial esters of methylenebisphosphonic acid.
(4) Synthesis of symmetrical di- and tetra- esters of methylenebisphosphonic acid.
Einzelnachweise
[1] SHELDRICK W. Crystal structure of methylenebis(phosphonic dichloride)[J]. Journal of The Chemical Society-dalton Transactions, 1975. DOI:10.1039/DT9750000943.

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Upstream-Materialien And Downstream Produkte

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1499-29-2, METHYLENEBIS(PHOSPHONIC DICHLORIDE) Verwandte Suche:

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